Title:
METHOD FOR PRODUCING PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2018/116511
Kind Code:
A1
Abstract:
Provided is a method for producing pluripotent stem cells whereby pluripotent stem cells having a function comparable to iPS cells can be obtained. The method for producing pluripotent stem cells comprises culturing animal cells in a medium containing a polyamine or a DNA methylation inhibitor and thus acquiring the pluripotent stem cells.
Inventors:
SHIOMI NAOFUMI (JP)
Application Number:
PCT/JP2017/026565
Publication Date:
June 28, 2018
Filing Date:
July 21, 2017
Export Citation:
Assignee:
KOBE COLLEGE (JP)
International Classes:
C12N5/00
Domestic Patent References:
| WO2010004989A1 | 2010-01-14 | |||
| WO2013100140A1 | 2013-07-04 |
Foreign References:
| JP2011050379A | 2011-03-17 |
Other References:
PLEWS, J. R. ET AL.: "Activation of Pluripotency Genes in Human Fibroblast Cells by a Novel mRNA Based Approach", PLOS ONE, vol. 5, no. 12, 2010, pages e14397, XP002635012
SHI, Y. ET AL.: "Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct 4 and Klf4 with Small-Molecule Compounds", CELL STEM CELL, vol. 3, 2008, pages 568 - 574, XP007913847
WANG, X. ET AL.: "The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene", IN VITRO CELL .DEV.BIOL.-ANIMAL, vol. 52, no. 4, 28 January 2016 (2016-01-28), pages 488 - 496, XP035943760
HOU, P. ET AL.: "Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds", SCIENCE, vol. 341, 2013, pages 651 - 654, XP055079363
FEDERATION, A. J. ET AL.: "The use of small molecules in somatic-cell reprogramming", TRENDS CELL BIOL., vol. 24, no. 3, 2014, pages 179 - 187, XP055510250
SHI, Y. ET AL.: "Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct 4 and Klf4 with Small-Molecule Compounds", CELL STEM CELL, vol. 3, 2008, pages 568 - 574, XP007913847
WANG, X. ET AL.: "The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene", IN VITRO CELL .DEV.BIOL.-ANIMAL, vol. 52, no. 4, 28 January 2016 (2016-01-28), pages 488 - 496, XP035943760
HOU, P. ET AL.: "Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds", SCIENCE, vol. 341, 2013, pages 651 - 654, XP055079363
FEDERATION, A. J. ET AL.: "The use of small molecules in somatic-cell reprogramming", TRENDS CELL BIOL., vol. 24, no. 3, 2014, pages 179 - 187, XP055510250
Attorney, Agent or Firm:
FUKAMI PATENT OFFICE, P.C. (JP)
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