Title:
METHOD FOR PRODUCING PREGNANE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/095435
Kind Code:
A1
Abstract:
A method for producing a pregnane derivative is characterized by the process wherein a pregnane derivative represented by the general formula (II) below is produced by silylating a compound represented by the formula (I) below using a silylating agent in the presence of a base and one or more solvents selected from hydrocarbons, ethers and esters, then the resulting reaction liquid is cooled so that the pregnane derivative represented by the general formula (II) below is precipitated as a solid in the reaction liquid, and then the thus-obtained precipitate is filtered out of the reaction liquid. (In the formula, R1, R2 and R3 independently represent an optionally substituted alkyl group or the like.)
Inventors:
SUGIOKA TAKASHI (JP)
KOYAKUMARU KENICHI (JP)
KOYAKUMARU KENICHI (JP)
Application Number:
PCT/JP2005/006808
Publication Date:
October 13, 2005
Filing Date:
March 31, 2005
Export Citation:
Assignee:
KURARAY CO (JP)
SUGIOKA TAKASHI (JP)
KOYAKUMARU KENICHI (JP)
SUGIOKA TAKASHI (JP)
KOYAKUMARU KENICHI (JP)
International Classes:
C07J9/00; (IPC1-7): C07J9/00
Foreign References:
| JPH09143154A | 1997-06-03 | |||
| JP2002533430A | 2002-10-08 | |||
| RU2221806C1 | 2004-01-20 |
Other References:
NAKAGAWA T. ET AL: "Shibozoku Oyobi Shi Kanshiki Seiri Kassei Busshitsu no Gosei Kenkyu.", 26 December 1991 (1991-12-26), pages 1 - 129, XP002998106
NAKAGAWA T. ET AL: "1alpha-Hydroxyvitamin D Yudotai no Gosei.", THE CHEMICAL SOCIETY OF JAPAN., 1991, pages 264 - 265, XP002998107
GEVORGYAN V. ET AL: "A Novel B(C6F5)3- Catalyzed Reduction of Alchohols and Cleavage of Aryl and Alkyl Ethers with Hydrosilanes.", J ORG CHEM., vol. 65, no. 18, 2000, pages 6179 - 6186, XP002998108
GREENE T.W.: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS.", 1991, JOHN WILEY & SONS, INC, CANADA, pages: 68 - 87, XP002998109
SHIOTANI S. ET AL: "ASYMEETRIC SYNTHESIS OF (+)-AND (-)-EPTAZOCINE VIA AN ENZYMATIC REACTION.", HETEROCYCLES., vol. 43, no. 1, 1996, pages 113 - 126, XP002998110
NAKAGAWA T. ET AL: "1alpha-Hydroxyvitamin D Yudotai no Gosei.", THE CHEMICAL SOCIETY OF JAPAN., 1991, pages 264 - 265, XP002998107
GEVORGYAN V. ET AL: "A Novel B(C6F5)3- Catalyzed Reduction of Alchohols and Cleavage of Aryl and Alkyl Ethers with Hydrosilanes.", J ORG CHEM., vol. 65, no. 18, 2000, pages 6179 - 6186, XP002998108
GREENE T.W.: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS.", 1991, JOHN WILEY & SONS, INC, CANADA, pages: 68 - 87, XP002998109
SHIOTANI S. ET AL: "ASYMEETRIC SYNTHESIS OF (+)-AND (-)-EPTAZOCINE VIA AN ENZYMATIC REACTION.", HETEROCYCLES., vol. 43, no. 1, 1996, pages 113 - 126, XP002998110
Attorney, Agent or Firm:
Takashima, Hajime (Osaka Midosuji Bldg. 1-1, Fushimimachi
4-chome, Chuo-ku, Osaka-sh, Osaka 44, JP)
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