Title:
METHOD OF PRODUCING PROANTHOCYANIDIN OLIGOMER
Document Type and Number:
WIPO Patent Application WO/2006/090830
Kind Code:
A1
Abstract:
A composition containing, as the main component, a proanthocyanidin oligomer which is obtained by heating a plant material containing a proanthocyanidin polymer or its extract together with a substance having a phloroglucinol ring or resorcinol ring structure in an acidic solution, carries the substance having the fluoro/resorcinol ring structure attached thereto and has been degraded; a method of producing the same; and use of the composition in health foods, drugs and so on. Thus, the proanthocyanidin oligomer having a biological activity, carrying the substance having a phloroglucinol ring or resorcinol ring structure attached to the terminus thereof and having been degraded to a level allowing the absorption in vivo, which can be hardly obtained from a plant material at a high yield, can be efficiently and easily obtained.
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Inventors:
TANAKA TAKASHI (JP)
NONAKA GEN-ICHIRO (JP)
KOHNO ISAO (JP)
FUJII HAJIME (JP)
NAKAGAWA TAKASHI (JP)
NISHIOKA HIROSHI (JP)
NONAKA GEN-ICHIRO (JP)
KOHNO ISAO (JP)
FUJII HAJIME (JP)
NAKAGAWA TAKASHI (JP)
NISHIOKA HIROSHI (JP)
Application Number:
PCT/JP2006/303402
Publication Date:
August 31, 2006
Filing Date:
February 24, 2006
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
USAIEN PHARMACEUTICAL CO LTD (JP)
AMINO UP CHEMICAL CO LTD (JP)
TANAKA TAKASHI (JP)
NONAKA GEN-ICHIRO (JP)
KOHNO ISAO (JP)
FUJII HAJIME (JP)
NAKAGAWA TAKASHI (JP)
NISHIOKA HIROSHI (JP)
USAIEN PHARMACEUTICAL CO LTD (JP)
AMINO UP CHEMICAL CO LTD (JP)
TANAKA TAKASHI (JP)
NONAKA GEN-ICHIRO (JP)
KOHNO ISAO (JP)
FUJII HAJIME (JP)
NAKAGAWA TAKASHI (JP)
NISHIOKA HIROSHI (JP)
International Classes:
C07D311/62; A61K8/00; A61K31/353; A61K36/00; A61P17/00; A61P25/00; A61P39/06; A61P43/00; A61Q19/00
Foreign References:
| JP2003504402A | 2003-02-04 | |||
| JP2000506901A | 2000-06-06 |
Other References:
HASHIMOTO F. ET AL.: "Evaluation of the anti-oxidative effect (in vitro) of tea polyphenols", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 67, no. 2, 2003, pages 396 - 401, XP002991340
STEYNBERG J.P.: "The first condensed tannins based on a stilbene", TETRAHEDRON LETTERS, vol. 24, no. 38, 1983, pages 4147 - 4150, XP002999629
KUBATA B.K. ET AL.: "Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 35, no. 1, January 2005 (2005-01-01), pages 91 - 103, XP004690106
FOO L.Y. ET AL.: "The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro", PHYTOCHEMISTRY, vol. 54, no. 2, 1 May 2000 (2000-05-01), pages 173 - 181, XP004291466
FOO L.Y. AND LU Y.: "Isolation and identification of procyanidins in apple pomace", FOOD CHEMISTRY, vol. 64, no. 4, 1999, pages 511 - 518, XP002999630
FOO L.Y. ET AL.: "Proanthocyanidins from Lotus corniculatus", PHYTOCHEMISTRY, vol. 41, no. 2, 1996, pages 617 - 624, XP002999631
FOO L.Y. ET AL.: "PROCYANIDIN POLYMERS OF DOUGLAS FIR BARK: STRUCTURE FROM DEGRADATION WITH PHLOROGLUCINOL", PHYTOCHEMISTRY, vol. 28, no. 11, 1989, pages 3185 - 3190, XP002999632
POLYA G.M. AND LAI YEAP FOO: "Inhibition of eukaryote signal-regulated protein kinases by plant-derived catechin-related compounds", PHYTOCHEMISTRY, vol. 35, no. 6, 1994, pages 1399 - 1405, XP008021995
STEYNBERG J.P.: "The first condensed tannins based on a stilbene", TETRAHEDRON LETTERS, vol. 24, no. 38, 1983, pages 4147 - 4150, XP002999629
KUBATA B.K. ET AL.: "Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 35, no. 1, January 2005 (2005-01-01), pages 91 - 103, XP004690106
FOO L.Y. ET AL.: "The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro", PHYTOCHEMISTRY, vol. 54, no. 2, 1 May 2000 (2000-05-01), pages 173 - 181, XP004291466
FOO L.Y. AND LU Y.: "Isolation and identification of procyanidins in apple pomace", FOOD CHEMISTRY, vol. 64, no. 4, 1999, pages 511 - 518, XP002999630
FOO L.Y. ET AL.: "Proanthocyanidins from Lotus corniculatus", PHYTOCHEMISTRY, vol. 41, no. 2, 1996, pages 617 - 624, XP002999631
FOO L.Y. ET AL.: "PROCYANIDIN POLYMERS OF DOUGLAS FIR BARK: STRUCTURE FROM DEGRADATION WITH PHLOROGLUCINOL", PHYTOCHEMISTRY, vol. 28, no. 11, 1989, pages 3185 - 3190, XP002999632
POLYA G.M. AND LAI YEAP FOO: "Inhibition of eukaryote signal-regulated protein kinases by plant-derived catechin-related compounds", PHYTOCHEMISTRY, vol. 35, no. 6, 1994, pages 1399 - 1405, XP008021995
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo 13, JP)
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