Title:
METHOD FOR PRODUCING RADIOPHARMACEUTICAL AND RADIOPHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2020/202831
Kind Code:
A1
Abstract:
Provided are a method for producing a radiopharmaceutical and a radiopharmaceutical, that during production and after production can preserve a radioactive compound which retains its chemical structure and radioactivity, and that can maintain the utilization period of the radiopharmaceutical. A method for producing a radiopharmaceutical that contains a radioactive component including a radioactive dithiosemicarbazone-copper complex, the method comprising a stabilization step of adding, to a solution containing the radioactive component, a stabilizer containing at least one compound selected from the group consisting of ascorbic acid, methionine, sodium ascorbate, mannitol, and butylhydroxyanisole; and a filtration step of filtering the solution containing the radioactive component or precursor thereof with a sterilization filter. The concentration of the radioactive component in the radiopharmaceutical is at least 200 MBq/mL as the radioactivity concentration.
Inventors:
YOSHII YUKIE (JP)
CHO MEIEI (JP)
KAWAMURA KAZUNORI (JP)
SUZUKI HISASHI (JP)
HASHIMOTO HIROKI (JP)
CHO MEIEI (JP)
KAWAMURA KAZUNORI (JP)
SUZUKI HISASHI (JP)
HASHIMOTO HIROKI (JP)
Application Number:
PCT/JP2020/005830
Publication Date:
October 08, 2020
Filing Date:
February 14, 2020
Export Citation:
Assignee:
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
International Classes:
A61P35/00; A61K9/08; A61K47/10; A61K47/20; A61K47/22; A61K47/26; A61K51/04
Foreign References:
| JP2014129316A | 2014-07-10 | |||
| JP2012514007A | 2012-06-21 | |||
| JP2015516457A | 2015-06-11 | |||
| JP2015081242A | 2015-04-27 | |||
| JP2012524064A | 2012-10-11 | |||
| JP2006528644A | 2006-12-21 |
Other References:
SCOTT, PETER, J. H. ET AL.: "Studies into radiolytic decomposition of fluorine-18 labeled radiopharmaceuticals for positron emission tomography", APPL RADIAT ISOT, vol. 67, no. 1, 2009, pages 88 - 94, XP025686472, DOI: 10.1016/j.apradiso.2008.08.015
CHEN, JIANQING ET AL.: "Synthsis, stabilization and formulation of [177Lu]Lu- AMBA, a systemic radiotherapeutic agent for gastrin releasing peptide receptor positive tumors", APPLIED RADIATION AND ISOTOPES, vol. 66, no. 4, 2008, pages 497 - 505, XP022498787
MOHSIN, FARHEEN ET AL.: "Comparison of stabilizers, Myo-Inositol and D-Mannitol for 99mTc-DMSA (III)", JOURNAL- CHEMICAL SOCIETY OF PAKISTAN, vol. 30, no. 6, 2008, pages 907 - 912, XP055746850
TAKAAT, H. M. ET AL.: "Synthesis of 99mTc-radiolabeled uridine as a potential tumor imaging agent", RADIOCHEMISTRY, vol. 60, no. 1, 2018, pages 51 - 57, XP036452182, DOI: 10.1134/S1066362218010095
CHEN, JIANQING ET AL.: "Synthsis, stabilization and formulation of [177Lu]Lu- AMBA, a systemic radiotherapeutic agent for gastrin releasing peptide receptor positive tumors", APPLIED RADIATION AND ISOTOPES, vol. 66, no. 4, 2008, pages 497 - 505, XP022498787
MOHSIN, FARHEEN ET AL.: "Comparison of stabilizers, Myo-Inositol and D-Mannitol for 99mTc-DMSA (III)", JOURNAL- CHEMICAL SOCIETY OF PAKISTAN, vol. 30, no. 6, 2008, pages 907 - 912, XP055746850
TAKAAT, H. M. ET AL.: "Synthesis of 99mTc-radiolabeled uridine as a potential tumor imaging agent", RADIOCHEMISTRY, vol. 60, no. 1, 2018, pages 51 - 57, XP036452182, DOI: 10.1134/S1066362218010095
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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