Title:
METHOD FOR PRODUCING RARE FATTY ACID USING NOVEL ENZYME, AND NOVEL RARE FATTY ACID
Document Type and Number:
WIPO Patent Application WO/2015/111699
Kind Code:
A1
Abstract:
The present invention provides: the production of a hydroxylated fatty acid by a hydration reaction using a novel enzyme which is derived from a lactic acid bacterium and of which the substrate is a fatty acid; and a method for producing an oxo fatty acid by an enzymatic reaction or a chemical oxidation reaction in which the hydroxylated fatty acid serves as a substrate. The present invention also provide a novel rare fatty acid which is produced by one of the above-mentioned methods and has a utility value.
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Inventors:
OGAWA JUN (JP)
KISHINO SHIGENOBU (JP)
KAWADA TERUO (JP)
TAKAHASHI NOBUYUKI (JP)
GOTO TSUYOSHI (JP)
YONEJIMA YASUNORI (JP)
KISHINO SHIGENOBU (JP)
KAWADA TERUO (JP)
TAKAHASHI NOBUYUKI (JP)
GOTO TSUYOSHI (JP)
YONEJIMA YASUNORI (JP)
Application Number:
PCT/JP2015/051842
Publication Date:
July 30, 2015
Filing Date:
January 23, 2015
Export Citation:
Assignee:
UNIV KYOTO (JP)
NITTO PHARMACEUTICAL IND LTD (JP)
NITTO PHARMACEUTICAL IND LTD (JP)
International Classes:
C12N15/09; C07C51/373; C07C59/185; C07C59/76; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12P7/64
Domestic Patent References:
| WO2013168310A1 | 2013-11-14 | |||
| WO2014069227A1 | 2014-05-08 | |||
| WO2014129384A1 | 2014-08-28 |
Foreign References:
| JP2006525805A | 2006-11-16 | |||
| JP2007259712A | 2007-10-11 | |||
| JP2007252333A | 2007-10-04 | |||
| JP2011184411A | 2011-09-22 |
Other References:
ANTON, VOLKOV ET AL.: "Crystal structure analysis of fatty acid double-bond hydratase from Lactobacillus acidophilus", ACTA CTYSTALLOGRAPHICA SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 69, no. 4, 2013, pages 648 - 657, XP055214876
JOO, YOUNG-CHUL ET AL.: "Biochemical characterization and FAD-binding analysis of oleate hydratase from Macrococcus caseolyticus", BIOCHIMIE, vol. 94, no. 3, 2012, pages 907 - 915, XP055214877
MICHIKI TAKEUCHI: "Functional analysis of linoleate hydratase from Lactobacillus plantarum AKU 1009a", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR BIOTECHNOLOGY, vol. 65 TH, 2013, JAPAN, pages 113, 2P-037, XP008184399
AKIKO HIRATA: "Lactobacillus acidophilus Yurai Shinki Linoleic Acid DELTA12 Suiwa Koso no Dotei to Kino Kaiseki", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR BIOTECHNOLOGY, vol. 66 TH, 2014, JAPAN, pages 80, 1P-248, XP008184523
HA YL, CARCINOGENESIS, vol. 8, no. 12, 1987, pages 1881 - 1887
CLEMENT IP, CANCER RES., vol. 51, 1991, pages 6118 - 6124
KISUN NL, ATHEROSCLEROSIS, vol. 108, 1994, pages 19 - 25
KIM Y-I, MOL. NUTR. FOOD RES., vol. 55, 2011, pages 585 - 593
KIM Y-I, PLOS ONE, vol. 7, no. 2, 2012, pages E31317
NOBUYUKI TAKAHASHI ET AL.: "Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes", FEBS LETTERS, vol. 514, 2002, pages 315 - 322
See also references of EP 3098313A4
JOO, YOUNG-CHUL ET AL.: "Biochemical characterization and FAD-binding analysis of oleate hydratase from Macrococcus caseolyticus", BIOCHIMIE, vol. 94, no. 3, 2012, pages 907 - 915, XP055214877
MICHIKI TAKEUCHI: "Functional analysis of linoleate hydratase from Lactobacillus plantarum AKU 1009a", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR BIOTECHNOLOGY, vol. 65 TH, 2013, JAPAN, pages 113, 2P-037, XP008184399
AKIKO HIRATA: "Lactobacillus acidophilus Yurai Shinki Linoleic Acid DELTA12 Suiwa Koso no Dotei to Kino Kaiseki", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR BIOTECHNOLOGY, vol. 66 TH, 2014, JAPAN, pages 80, 1P-248, XP008184523
HA YL, CARCINOGENESIS, vol. 8, no. 12, 1987, pages 1881 - 1887
CLEMENT IP, CANCER RES., vol. 51, 1991, pages 6118 - 6124
KISUN NL, ATHEROSCLEROSIS, vol. 108, 1994, pages 19 - 25
KIM Y-I, MOL. NUTR. FOOD RES., vol. 55, 2011, pages 585 - 593
KIM Y-I, PLOS ONE, vol. 7, no. 2, 2012, pages E31317
NOBUYUKI TAKAHASHI ET AL.: "Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes", FEBS LETTERS, vol. 514, 2002, pages 315 - 322
See also references of EP 3098313A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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