Title:
METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELL SHEET
Document Type and Number:
WIPO Patent Application WO/2014/030749
Kind Code:
A1
Abstract:
The invention provides a method for producing a cell sheet including a retinal pigment epithelial cell layer and an angiogenic cell layer, the method including a step for laminating a retinal pigment epithelial cell layer and an angiogenic cell layer constructed of blood vessel component cells or stem cells having angiogenic potency; and provides a cell sheet obtained by this method. The invention also provides a cell sheet for transplantation including a cell layer formed by retinal pigment epithelial cells obtained by inducing in vitro differentiation of stem cells or progenitor cells, a basement membrane secreted from these cells, and an angiogenic cell layer constructed of blood vessel component cells or stem cells having angiogenic potency.
More Like This:
Inventors:
TAKAHASHI MASAYO (JP)
KAMAO HIROYUKI (JP)
KAMAO HIROYUKI (JP)
Application Number:
PCT/JP2013/072589
Publication Date:
February 27, 2014
Filing Date:
August 23, 2013
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
C12N5/10; A61K35/44; A61L27/00; A61P27/02; C12N5/071
Domestic Patent References:
| WO2011142364A1 | 2011-11-17 | |||
| WO2012115244A1 | 2012-08-30 | |||
| WO2011142364A1 | 2011-11-17 | |||
| WO2008056779A1 | 2008-05-15 | |||
| WO2009035217A1 | 2009-03-19 |
Foreign References:
| JPH09501303A | 1997-02-10 | |||
| JP2005538742A | 2005-12-22 | |||
| JP2005538742A | 2005-12-22 | |||
| JPH02211865A | 1990-08-23 | |||
| JPH05192138A | 1993-08-03 | |||
| JP2008220354A | 2008-09-25 | |||
| JP2007500509A | 2007-01-18 | |||
| JP2007517210A | 2007-06-28 |
Other References:
SATOSHI OKAMOTO ET AL.: "Karei Ohan Hensei", EXPERIMENTAL MEDICINE, vol. 30, no. 10, 2012, pages 138 - 142, XP008178297
TADASHI SASAGAWA ET AL.: "Saibo Sheet Sekisoka Soshikinai ni Okeru Kekkan Naihi Saibo Network Keisei ni Kakawaru Bunshi No Tansaku", REGENERATIVE MEDICINE, vol. 11, 2012, pages 250, XP008178096
AM J OPHTHALMOL., vol. 153, no. 1, January 2012 (2012-01-01), pages 120 - 7
ACTA OPHTHALMOL., vol. 89, no. 6, September 2011 (2011-09-01), pages E490 - 5
BR J OPHTHALMOL., vol. 95, no. 3, March 2011 (2011-03-01), pages 370 - 5
SCIENCE., vol. 275, no. 5302, 14 February 1997 (1997-02-14), pages 964 - 7
N ENGL J MED., vol. 348, 2003, pages 593 - 600
STEM CELLS DEV., vol. 13, no. 3, June 2004 (2004-06-01), pages 229 - 42
TAKAHASHI, K.; YAMANAKA, S., CELL, vol. 126, 2006, pages 663 - 676
TAKAHASHI, K. ET AL., CELL, vol. 131, 2007, pages 861 - 872
NEUROSCIENCE LETTERS, vol. 458, no. 3, 24 July 2009 (2009-07-24), pages 126 - 31
JOURNAL OF CELL SCIENCE, vol. 122, 1 September 2009 (2009-09-01), pages 3169 - 79
"Japan tissue culture conference ed., Technique of Tissue Culture 3rd edition", ASAKURA SHOTEN, pages: 581
INVEST. OPHTHALMOL. VIS. SCI., vol. 36, no. 2, 1995, pages 381 - 390
HIROSHI IRIE: "Radioimmunoassay", 1974, KODANSHA
HIROSHI IRIE: "cont. Radioimmunoassay", 1979, KODANSHA
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay", 1978, IGAKU-SHOIN
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay, 2ND ED.", 1982, IGAKU-SHOIN
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay, 3rd ed.", 1987, IGAKU-SHOIN
"Methods in ENZYMOLOGY", vol. 70, article "Immunochemical Techniques (Part A)"
"METHODS IN ENZYMOLOGY", vol. 73, article "Immunochemical Techniques(Part B)"
"METHODS IN ENZYMOLOGY", vol. 74, article "Immunochemical Techniques (Part C)"
"METHODS IN ENZYMOLOGY", vol. 84, article "Immunochemical Techniques (Part D: Selected Immunoassays"
"METHODS IN ENZYMOLOGY", vol. 92, article "Immunochemical Techniques (Part E: Monoclonal Antibodies and General Immunoassay Methods"
"METHODS IN ENZYMOLOGY", vol. 121, ACADEMIC PRESS, article "Immunochemical Techniques (Part I: Hybridoma Technology and Monoclonal Antibodies"
NEUROSCIENCE LETTERS, vol. 458, 2009, pages 126 - 131
NATURE BIOTECHNOLOGY, vol. 26, 2008, pages 101 - 106
PROC. JPN. ACAD., SER. B, vol. 85, 2009, pages 348 - 362
NAT METHODS., vol. 8, no. 5, May 2011 (2011-05-01), pages 409 - 12
JPN. J. TRANSPLANT, vol. 44, 2009, pages 231 - 235
ARVYDAS M, IOVS, vol. 47, 2006, pages 3612 - 3624
NATURE PROTOCOLS, vol. 4, no. 5, 2009, pages 662 - 673
INVEST OPHTHALMOL VIS SCI., vol. 36, no. 2, February 1995 (1995-02-01), pages 381 - 90
TADASHI SASAGAWA ET AL.: "Saibo Sheet Sekisoka Soshikinai ni Okeru Kekkan Naihi Saibo Network Keisei ni Kakawaru Bunshi No Tansaku", REGENERATIVE MEDICINE, vol. 11, 2012, pages 250, XP008178096
AM J OPHTHALMOL., vol. 153, no. 1, January 2012 (2012-01-01), pages 120 - 7
ACTA OPHTHALMOL., vol. 89, no. 6, September 2011 (2011-09-01), pages E490 - 5
BR J OPHTHALMOL., vol. 95, no. 3, March 2011 (2011-03-01), pages 370 - 5
SCIENCE., vol. 275, no. 5302, 14 February 1997 (1997-02-14), pages 964 - 7
N ENGL J MED., vol. 348, 2003, pages 593 - 600
STEM CELLS DEV., vol. 13, no. 3, June 2004 (2004-06-01), pages 229 - 42
TAKAHASHI, K.; YAMANAKA, S., CELL, vol. 126, 2006, pages 663 - 676
TAKAHASHI, K. ET AL., CELL, vol. 131, 2007, pages 861 - 872
NEUROSCIENCE LETTERS, vol. 458, no. 3, 24 July 2009 (2009-07-24), pages 126 - 31
JOURNAL OF CELL SCIENCE, vol. 122, 1 September 2009 (2009-09-01), pages 3169 - 79
"Japan tissue culture conference ed., Technique of Tissue Culture 3rd edition", ASAKURA SHOTEN, pages: 581
INVEST. OPHTHALMOL. VIS. SCI., vol. 36, no. 2, 1995, pages 381 - 390
HIROSHI IRIE: "Radioimmunoassay", 1974, KODANSHA
HIROSHI IRIE: "cont. Radioimmunoassay", 1979, KODANSHA
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay", 1978, IGAKU-SHOIN
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay, 2ND ED.", 1982, IGAKU-SHOIN
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay, 3rd ed.", 1987, IGAKU-SHOIN
"Methods in ENZYMOLOGY", vol. 70, article "Immunochemical Techniques (Part A)"
"METHODS IN ENZYMOLOGY", vol. 73, article "Immunochemical Techniques(Part B)"
"METHODS IN ENZYMOLOGY", vol. 74, article "Immunochemical Techniques (Part C)"
"METHODS IN ENZYMOLOGY", vol. 84, article "Immunochemical Techniques (Part D: Selected Immunoassays"
"METHODS IN ENZYMOLOGY", vol. 92, article "Immunochemical Techniques (Part E: Monoclonal Antibodies and General Immunoassay Methods"
"METHODS IN ENZYMOLOGY", vol. 121, ACADEMIC PRESS, article "Immunochemical Techniques (Part I: Hybridoma Technology and Monoclonal Antibodies"
NEUROSCIENCE LETTERS, vol. 458, 2009, pages 126 - 131
NATURE BIOTECHNOLOGY, vol. 26, 2008, pages 101 - 106
PROC. JPN. ACAD., SER. B, vol. 85, 2009, pages 348 - 362
NAT METHODS., vol. 8, no. 5, May 2011 (2011-05-01), pages 409 - 12
JPN. J. TRANSPLANT, vol. 44, 2009, pages 231 - 235
ARVYDAS M, IOVS, vol. 47, 2006, pages 3612 - 3624
NATURE PROTOCOLS, vol. 4, no. 5, 2009, pages 662 - 673
INVEST OPHTHALMOL VIS SCI., vol. 36, no. 2, February 1995 (1995-02-01), pages 381 - 90
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
Download PDF: