Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR PRODUCING RETINAL TISSUES
Document Type and Number:
WIPO Patent Application WO/2019/054514
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for suppressing differentiation of ganglion cells, amacrine cells, horizontal cells, and/or bipolar cells in neural retinal tissues including photoreceptor precursor cells and/or photoreceptor cells, etc. This method for suppressing differentiation of ganglion cells, amacrine cells, horizontal cells, and/or bipolar cells in neural retinal tissues including photoreceptor precursor cells and/or photoreceptor cells comprises a step for culturing, in a medium containing a thyroid hormone signal transduction pathway active substance, retinal tissues that contains neural retinal precursor cells and are in any one of differentiation stages from a differentiation stage just after the emergence of ganglion cells to a stage at which the occurrence rate of pyramidal photoreceptor precursor cells reaches the maximum.

More Like This:
WO/2012/096705DIFFERENTIATION METHODS FOR PRODUCTION OF GLIAL CELL POPULATIONS
WO/2018/026784IN SITU CELL DELIVERY USING RECONSTITUTED PHOTOPOLYMERIZED CHONDROITIN SULFATE GLYCOSAMINOGLYCAN HYDROGEL MATRICES
JP2022529662Methods and Compositions for Double Glycan-Binding AAV2.5 Vectors
Inventors:
NUKAYA DAIKI (JP)
EIRAKU MOTOTSUGU (JP)
KINOSE YUIKO (JP)
ONISHI AKISHI (JP)
TAKAHASHI MASAYO (JP)
SASAI YOSHIKI (笹井　芳樹)
Application Number:
PCT/JP2018/034314
Publication Date:
March 21, 2019
Filing Date:
September 14, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
RIKEN (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
SUMITOMO CHEMICAL CO (JP)
International Classes:
C12N5/079; A61K35/30; A61P27/02; C12Q1/02
Domestic Patent References:
WO2016063986A12016-04-28
WO2017043604A12017-03-16
WO1996022362A11996-07-25
WO2002101057A12002-12-19
WO1998030679A11998-07-16
WO1997021993A21997-06-19
WO2004066929A22004-08-12
WO2004093799A22004-11-04
WO2000039077A22000-07-06
WO2001098256A12001-12-27
WO2003018515A22003-03-06
WO2003084915A12003-10-16
WO2002094319A12002-11-28
WO2003064369A12003-08-07
WO2007132475A12007-11-22
WO2007009913A12007-01-25
WO2003094845A22003-11-20
WO2002051805A12002-07-04
WO2010122980A12010-10-28
WO2013077425A12013-05-30
WO2015025967A12015-02-26
WO2016063985A12016-04-28
WO2016063986A12016-04-28
WO2017183732A12017-10-26
WO2015087614A12015-06-18
WO2013183774A12013-12-12
WO2015107738A12015-07-23
Foreign References:
JP2003521910A2003-07-22
US5843780A1998-12-01
US6200806B12001-03-13
US6280718B12001-08-28
JP2001508302A2001-06-26
JP2002053564A2002-02-19
JP2002370978A2002-12-24
JP2000256190A2000-09-19
US20140341864A12014-11-20
US20160251616A12016-09-01
US20160376554A12016-12-29
US20150132787A12015-05-14
US201415112187A2014-10-16
JP2017177188A2017-10-05
Other References:
YANAI, ANAT ET AL.: "Differentiation of Human Embryonic Stem Cells Using Size-Controlled Embryoid Bodies and Negative Cell Selection in the Production of Photoreceptor Precursor Cells", TISSUE ENGINEERING: PART C, vol. 19, no. 10, 15 March 2013 (2013-03-15), pages 755 - 764, XP055583046, DOI: 10.1089/ten.TEC.2012.0524
KELLEY, MATTHEW W. ET AL.: "Regulation of Proliferation and Photoreceptor Differentiation in Fetal Human Retinal Cell Cultures", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 36, no. 7, June 1995 (1995-06-01), pages 1280 - 1289, XP055583052
JOHE, KARL K. ET AL.: "Single factors direct the differentiation of stem cells from the fetal and adult central nervous system", GENES & DEVELOPMENT, vol. 10, 1996, pages 3129 - 3140, XP002037767, DOI: 10.1101/gad.10.24.3129
PROG RETIN EYE RES, vol. 17, no. 2, 1998, pages 175 - 205
PROC NATL ACAD SCI U S A, vol. 113, no. 1, 2016, pages E 81 - 9 0
INVEST OPHTHALMOL VIS SCI, vol. 36, no. 7, 1995, pages 1280 - 1289
DEVELOPMENT, vol. 120, no. 8, 1994, pages 2091 - 2102
STEM CELLS, vol. 31, 2013, pages 458 - 466
YAMANAKA ET AL., MOUSE CELL, 2006
CELL, vol. 126, no. 4, 2006, pages 663 - 676
CELL, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NAT. BIOTECHNOL., vol. 26, no. 1, 2008, pages 101 - 106
CELL, vol. 126, no. 4, 25 August 2006 (2006-08-25), pages 663 - 76
CELL, vol. 131, no. 5, 30 November 2007 (2007-11-30), pages 861 - 72
SCIENCE, vol. 341, 2013, pages 651 - 654
"Mouse Embryo, A Laboratory Manual", 1994, COLD SPRING HARBOR LABORATORY PRESS
J. NEUROSCI. RES., vol. 35, 1993, pages 567 - 576
"Biomanual Series 8, Gene Targeting, Making of Mutant Mouse using ES cell", 1995, YODOSHA CO., LTD.
"Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
NAKANO, T. ET AL., CELL STEM CELL, vol. 10, no. 6, 2012, pages 771 - 785
NAT COMMUN., vol. 6, 2015, pages 6286
PROC NATL ACAD SCI U S A., vol. 111, no. 23, 2014, pages 8518 - 8523
NAT COMMUN., vol. 5, 2014, pages 4047
STEM CELLS, vol. 35, no. 5, 2017, pages 1176 - 1188
NATURE METHODS, vol. 8, 2011, pages 424 - 429
PROC. NATL. ACAD. SCI. USA., vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
NAT BIOTECHNOL, vol. 28, 2010, pages 611 - 615
NAT COMMUN, vol. 3, 2012, pages 1236
NAT BIOTECHNOL, vol. 19, 2001, pages 971 - 974
NEURON, vol. 87, no. 6, 2015, pages 1248 - 60
UENO, M. ET AL., PNAS, vol. 103, no. 25, 2006, pages 9554 - 9559
WATANABE, K. ET AL., NAT BIOTECH, vol. 25, 2007, pages 681 - 686
KUWAHARA ET AL., NAT COMMUN, vol. 19, no. 6, 2015, pages 6286
See also references of EP 3683306A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: CONNECTOR AND METHOD FOR CONNECTING CONNECTOR

Next Patent: METHOD FOR AMPLIFYING CONE PHOTORECEPTORS OR ROD PHOTORECEPTORS USING DORSALIZATION SIGNAL TRANSMITT...