Title:
METHOD OF PRODUCING SELF-ASSEMBLING PEPTIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/010721
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an efficient production method capable of obtaining economically and in large quantities self-assembling peptide derivatives that are useful in the fields of regenerative medicine and surgery. The provided production method combines (i) a convergent sequence construction step in which an amino acid sequence common unit is used, and (ii) a step in which after isolation as salts such as 2-sulfate, 4-methanesulfonic acid salt or 4 trifluoroacetic acid (TFA) salt, salt exchange with 4-hydrochloride is performed.
Inventors:
YOKOI HIDENORI (JP)
YOKOYAMA YASUHIRO (JP)
MATSUYAMA KEISUKE (JP)
YAMAMOTO KENICHIRO (JP)
ANZAI KINSEI (JP)
NAKAMURA DAISUKE (JP)
NAGANO TOYOHIRO (JP)
KODAMA KAZUYA (JP)
YOKOYAMA YASUHIRO (JP)
MATSUYAMA KEISUKE (JP)
YAMAMOTO KENICHIRO (JP)
ANZAI KINSEI (JP)
NAKAMURA DAISUKE (JP)
NAGANO TOYOHIRO (JP)
KODAMA KAZUYA (JP)
Application Number:
PCT/JP2013/069124
Publication Date:
January 16, 2014
Filing Date:
July 12, 2013
Export Citation:
Assignee:
MENICON CO LTD (JP)
NAGASE & CO LTD (JP)
NAGASE CHEMTEX CORP (JP)
NAGASE & CO LTD (JP)
NAGASE CHEMTEX CORP (JP)
International Classes:
C07K7/08; A61K38/00; C07K5/08; C07K7/06
Domestic Patent References:
| WO2010103887A1 | 2010-09-16 | |||
| WO2002090985A1 | 2002-11-14 | |||
| WO2010103887A1 | 2010-09-16 |
Other References:
NOBUO IZUMIYA ET AL.: "Peptide Gosei no Kiso to Jikken", MARUZEN CO., LTD, 20 January 1985 (1985-01-20), pages 146 - 153, 222 TO 223, XP008176206
"Shin Seikagaku Jikken Koza 1 Tanpakushitsu VI, Gosei Oyobi Hatsugen", KABUSHIKI KAISHA TOKYO KAGAKU DOJIN, 15 June 1992 (1992-06-15), TOKYO KAGAKU DOJIN, pages 3 - 29, 66 TO 74, XP008176221
HAN, SO-YEOP ET AL.: "Recent development of peptide coupling reagents in organic synthesis.", TETRAHEDRON, vol. 60, no. 11, 2004, pages 2447 - 2467, XP004492575
NAGAI YUSUKE ET AL.: "The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel.", BIOMATERIALS, vol. 33, no. 4, February 2012 (2012-02-01), pages 1044 - 1051, XP028115482
M. FUJINO ET AL., CHEM. PHARM. BULL., vol. 29, 1981, pages 2825
R. RAMAGE, TETRAHEDRON LETT., vol. 28, 1987, pages 2287
"Shin Seikagaku Jikken Koza 1 Tanpakushitsu VI, Gosei Oyobi Hatsugen", KABUSHIKI KAISHA TOKYO KAGAKU DOJIN, 15 June 1992 (1992-06-15), TOKYO KAGAKU DOJIN, pages 3 - 29, 66 TO 74, XP008176221
HAN, SO-YEOP ET AL.: "Recent development of peptide coupling reagents in organic synthesis.", TETRAHEDRON, vol. 60, no. 11, 2004, pages 2447 - 2467, XP004492575
NAGAI YUSUKE ET AL.: "The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel.", BIOMATERIALS, vol. 33, no. 4, February 2012 (2012-02-01), pages 1044 - 1051, XP028115482
M. FUJINO ET AL., CHEM. PHARM. BULL., vol. 29, 1981, pages 2825
R. RAMAGE, TETRAHEDRON LETT., vol. 28, 1987, pages 2287
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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