Title:
METHOD FOR PRODUCING SEPIAPTERIN AND TETRAHYDROLACTOYLPTERIN
Document Type and Number:
WIPO Patent Application WO/2013/168693
Kind Code:
A1
Abstract:
Provided is a method for producing sepiapterin, lactoylpterin, and tetrahydrolactoylpterin. Sepiapterin, lactoylpterin, and tetrahydrolactoylpterin are obtained at a good yield by the reaction formula.
Inventors:
YOSHINO HIROSHI (JP)
KOMODA TAICHI (JP)
SHIRO YUICHI (JP)
MURATA SHUNICHI (JP)
MURATA SHIZUAKI (JP)
KURODA YASUHIRO (JP)
KOMODA TAICHI (JP)
SHIRO YUICHI (JP)
MURATA SHUNICHI (JP)
MURATA SHIZUAKI (JP)
KURODA YASUHIRO (JP)
Application Number:
PCT/JP2013/062817
Publication Date:
November 14, 2013
Filing Date:
May 07, 2013
Export Citation:
Assignee:
SHIRATORI PHARM (JP)
International Classes:
C07D475/04; A61K31/519; A61P25/00
Domestic Patent References:
| WO2011132435A1 | 2011-10-27 | |||
| WO2005049614A2 | 2005-06-02 | |||
| WO2011132435A1 | 2011-10-27 |
Foreign References:
| JPS61172877A | 1986-08-04 | |||
| JP2011011976A | 2011-01-20 |
Other References:
FAN, C.L. ET AL.: "Partial purification and some properties of biopterin synthase and dihydropterin oxidase from Drosophila melanogaster", BIOCHEMICAL GENETICS, vol. 17, no. 3-4, 1979, pages 351 - 369, XP008175190
LANDGE,S.S. ET AL.: "Chemoselective oxidation of 6-hydroxyalkylpteridine and its application to synthesis of 6-acyl-7,8-dihydropteridine", HETEROCYCLES, vol. 71, no. 4, 2007, pages 911 - 918, XP008175195
CHOI,Y.K. ET AL.: "Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2", BIOCHIMICA ET BIOPHYSICA ACTA, GENERAL SUBJECTS, vol. 1760, no. 6, 2006, pages 877 - 882, XP025015007
SATO,N. ET AL.: "Studies on pyrazines. 17. An efficient synthesis of pteridine-6-carboxylic acids", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 25, no. 6, 1988, pages 1737 - 1740, XP002049102
PFLEIDERER,W. ET AL.: "Pteridines. LXVIII. Transformation of biopterin into sepiapterin and absolute configuration of sepiapterin", CHEMISCHE BERICHTE, vol. 112, no. 7, 1979, pages 2750 - 2755, XP055172499
NAIR,M.G. ET AL.: "Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 6, 1989, pages 1277 - 1283, XP055172502
JOURNAL OF THE CHEMICAL SOCIETY OF JAPAN, 1972, pages 206 - 208
HELVETICA CHIMICA ACTA, vol. 61, no. 7, 1978, pages 2731
ZOOLOGICAL MAGAZINE, vol. 86, 1977, pages 29
BIOCHEMICAL GENETICS, vol. 17, 1979, pages 351
HETEROCYCLES, vol. 71, no. 4, 2007, pages 911
TETRAHEDRON LETTERS, vol. 7847, 2004
LANDGE,S.S. ET AL.: "Chemoselective oxidation of 6-hydroxyalkylpteridine and its application to synthesis of 6-acyl-7,8-dihydropteridine", HETEROCYCLES, vol. 71, no. 4, 2007, pages 911 - 918, XP008175195
CHOI,Y.K. ET AL.: "Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2", BIOCHIMICA ET BIOPHYSICA ACTA, GENERAL SUBJECTS, vol. 1760, no. 6, 2006, pages 877 - 882, XP025015007
SATO,N. ET AL.: "Studies on pyrazines. 17. An efficient synthesis of pteridine-6-carboxylic acids", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 25, no. 6, 1988, pages 1737 - 1740, XP002049102
PFLEIDERER,W. ET AL.: "Pteridines. LXVIII. Transformation of biopterin into sepiapterin and absolute configuration of sepiapterin", CHEMISCHE BERICHTE, vol. 112, no. 7, 1979, pages 2750 - 2755, XP055172499
NAIR,M.G. ET AL.: "Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 6, 1989, pages 1277 - 1283, XP055172502
JOURNAL OF THE CHEMICAL SOCIETY OF JAPAN, 1972, pages 206 - 208
HELVETICA CHIMICA ACTA, vol. 61, no. 7, 1978, pages 2731
ZOOLOGICAL MAGAZINE, vol. 86, 1977, pages 29
BIOCHEMICAL GENETICS, vol. 17, 1979, pages 351
HETEROCYCLES, vol. 71, no. 4, 2007, pages 911
TETRAHEDRON LETTERS, vol. 7847, 2004
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
Download PDF:
Previous Patent: OBJECTIVE LENS AND OPTICAL PICKUP DEVICE
Next Patent: NON-SUGAR ENERGY-PRODUCTION-ENHANCING AGENT
Next Patent: NON-SUGAR ENERGY-PRODUCTION-ENHANCING AGENT