Title:
METHOD FOR PRODUCING SOPHOROSE LIPID
Document Type and Number:
WIPO Patent Application WO/2010/050413
Kind Code:
A1
Abstract:
Provided is an efficient method for producing a glycolipid biosurfactant, particularly a lactonic sophorose lipid at a low cost, wherein the method includes culturing a microorganism which produces the biosurfactant by limiting oxygen supply. According to the invention, a lactonic sophorose lipid can be preferentially produced, and further, the lactonic sophorose lipid can be easily recovered in a solid form. In addition, by hydrolyzing the thus obtained high-purity lactonic sophorose lipid, a high-purity acidic sophorose lipid can be produced. Further, a lactonic sophorose lipid having potent antibacterial or antifungal activity and an antibacterial agent and/or an antifungal agent containing the sophorose lipid are provided.
Inventors:
YANAGISAWA SATOHIRO (JP)
KAWANO SHIGERU (JP)
YASOHARA YOSHIHIKO (JP)
KAWANO SHIGERU (JP)
YASOHARA YOSHIHIKO (JP)
Application Number:
PCT/JP2009/068260
Publication Date:
May 06, 2010
Filing Date:
October 23, 2009
Export Citation:
Assignee:
KANEKA CORP (JP)
YANAGISAWA SATOHIRO (JP)
KAWANO SHIGERU (JP)
YASOHARA YOSHIHIKO (JP)
YANAGISAWA SATOHIRO (JP)
KAWANO SHIGERU (JP)
YASOHARA YOSHIHIKO (JP)
International Classes:
C12P19/44; A01N43/16; A01P3/00; A61K8/60; A61K31/7016; A61P31/04; A61P31/10; A61Q1/00; A61Q5/00; C07H15/04; C09K3/00; C11C3/00; C11D1/06; C11D1/68; C12R1/72; C12R1/88
Domestic Patent References:
| WO2004044216A1 | 2004-05-27 | |||
| WO2006069175A2 | 2006-06-29 |
Foreign References:
| JP2001522597A | 2001-11-20 | |||
| JPS5428895A | 1979-03-03 |
Other References:
DANIEL, H.J. ET AL.: "Production of sophorolipids from whey: development of a two-stage process with Cryptococcus curvatus ATCC 20509 and Candida bombicola ATCC 22214 using deproteinized whey concentrates as substrates", APPL.MICROBIOL.BIOTECHNOL., vol. 51, no. 1, 1999, pages 40 - 45, XP008104228
DANIEL, H.J. ET AL.: "Production of sophorolipids in high concentration from deproteinized whey and rapeseed oil in a two stage fed batch process using Candida bombicola ATCC 22214 and Cryptococcus curvatus ATCC 20509", BIOTECHNOL.LETT., vol. 20, no. 12, 1998, pages 1153 - 1156, XP008139502
PEKIN, G. ET AL.: "Production of sophorolipids from Candida bombicola ATCC 22214 using Turkish corn oil and honey", ENG.LIFE SCI., vol. 5, no. 4, 2005, pages 357 - 362, XP008139495
VAN BOGAERT, I.N.A. ET AL.: "Microbial production and application of sophorolipids", APPL.MICROBIOL.BIOTECHNOL., vol. 76, no. 1, 2007, pages 23 - 34, XP019538805
CASAS, J.A. ET AL.: "Sophorolipid production by Candida bombicola: medium composition and culture methods", J.BIOSCI.BIOENG., vol. 88, no. 5, 1999, pages 488 - 494, XP008139506
CASAS, J.A. ET AL.: "Optimization of a synthetic medium for Candida bombicola growth using factorial design of experiments", ENZYME MICROB. TECHNOL., vol. 21, no. 3, 1997, pages 221 - 229, XP008139499
MCCAFFREY, W.C. ET AL.: "Sophorolipids production by Candida bombicola using self- cycling fermentation", J.FERMENT.BIOENG., vol. 79, no. 2, 1995, pages 146 - 151, XP002054166
CAVALERO, D.A. ET AL.: "The effect of medium composition on the structure and physical state of sophorolipids produced by Candida bombicola ATCC 22214", J.BIOTECHNOL., vol. 103, no. 1, 2003, pages 31 - 41, XP008139519
SHAH, V. ET AL.: "Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities", ANTIMICROB.AGENTS CHEMOTHER., vol. 49, no. 10, 2005, pages 4093 - 4100, XP002601797
GLENNS, R.N. ET AL.: "Effect of substrate on sophorolipid properties", J.AM.OIL CHEM.SOC., vol. 83, no. 2, 2006, pages 137 - 145, XP008139518
JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 65, no. 9, 1988, pages 1460
JOURNAL OF INDUSTRIAL MICROBIOLOGY, vol. 13, 1994, pages 249
CANADIAN JOURNAL OF CHEMISTRY, vol. 39, 1961, pages 846
JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 83, no. 2, 2006, pages 137
ENGINEERING IN LIFE SCIENCES, vol. 5, no. 4, 2005, pages 357
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 76, 2007, pages 23
FETT WISSENSCHAFT TECHNOLOGIE, vol. 91, 1989, pages 363
J. CHROMATOGR., vol. 648, 1993, pages 139
See also references of EP 2351847A4
DANIEL, H.J. ET AL.: "Production of sophorolipids in high concentration from deproteinized whey and rapeseed oil in a two stage fed batch process using Candida bombicola ATCC 22214 and Cryptococcus curvatus ATCC 20509", BIOTECHNOL.LETT., vol. 20, no. 12, 1998, pages 1153 - 1156, XP008139502
PEKIN, G. ET AL.: "Production of sophorolipids from Candida bombicola ATCC 22214 using Turkish corn oil and honey", ENG.LIFE SCI., vol. 5, no. 4, 2005, pages 357 - 362, XP008139495
VAN BOGAERT, I.N.A. ET AL.: "Microbial production and application of sophorolipids", APPL.MICROBIOL.BIOTECHNOL., vol. 76, no. 1, 2007, pages 23 - 34, XP019538805
CASAS, J.A. ET AL.: "Sophorolipid production by Candida bombicola: medium composition and culture methods", J.BIOSCI.BIOENG., vol. 88, no. 5, 1999, pages 488 - 494, XP008139506
CASAS, J.A. ET AL.: "Optimization of a synthetic medium for Candida bombicola growth using factorial design of experiments", ENZYME MICROB. TECHNOL., vol. 21, no. 3, 1997, pages 221 - 229, XP008139499
MCCAFFREY, W.C. ET AL.: "Sophorolipids production by Candida bombicola using self- cycling fermentation", J.FERMENT.BIOENG., vol. 79, no. 2, 1995, pages 146 - 151, XP002054166
CAVALERO, D.A. ET AL.: "The effect of medium composition on the structure and physical state of sophorolipids produced by Candida bombicola ATCC 22214", J.BIOTECHNOL., vol. 103, no. 1, 2003, pages 31 - 41, XP008139519
SHAH, V. ET AL.: "Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities", ANTIMICROB.AGENTS CHEMOTHER., vol. 49, no. 10, 2005, pages 4093 - 4100, XP002601797
GLENNS, R.N. ET AL.: "Effect of substrate on sophorolipid properties", J.AM.OIL CHEM.SOC., vol. 83, no. 2, 2006, pages 137 - 145, XP008139518
JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 65, no. 9, 1988, pages 1460
JOURNAL OF INDUSTRIAL MICROBIOLOGY, vol. 13, 1994, pages 249
CANADIAN JOURNAL OF CHEMISTRY, vol. 39, 1961, pages 846
JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 83, no. 2, 2006, pages 137
ENGINEERING IN LIFE SCIENCES, vol. 5, no. 4, 2005, pages 357
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 76, 2007, pages 23
FETT WISSENSCHAFT TECHNOLOGIE, vol. 91, 1989, pages 363
J. CHROMATOGR., vol. 648, 1993, pages 139
See also references of EP 2351847A4
Attorney, Agent or Firm:
KANEKA CORPORATION (JP)
KANEKA Co. (JP)
KANEKA Co. (JP)
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