Title:
METHOD FOR PRODUCING STARCH GRANULES, AND ORALLY DISINTEGRATING TABLET
Document Type and Number:
WIPO Patent Application WO/2013/161805
Kind Code:
A1
Abstract:
A method for producing starch granules suitable as an excipient for an orally disintegrating tablet. A paste is sprayed in small amounts while β-starch is being fluidized using an air-fluidized bed to carry out fluidized bed granulation. Thereafter, fluidized bed drying is carried out at the gelatinization temperature of the β-starch or higher. This results in starch granules having a high degree of gelatinization in comparison with the amount of gelatinized starch adhered to the β-starch by the spraying of the paste. These starch granules alone impart an adequate oral disintegration performance and breaking strength to the tablet. Consequently, in instances of use as an excipient for tableting of orally disintegrating tablets, another auxiliary excipient such as crystalline cellulose or a sugar or the like need not be added.
Inventors:
UMEZAKI MASAO (JP)
MURASE HIROSHIGE (JP)
UNO TOSHIO (JP)
NIWA TOSHIYUKI (JP)
MURASE HIROSHIGE (JP)
UNO TOSHIO (JP)
NIWA TOSHIYUKI (JP)
Application Number:
PCT/JP2013/061900
Publication Date:
October 31, 2013
Filing Date:
April 23, 2013
Export Citation:
Assignee:
JAPAN CORN STARCH CO LTD (JP)
International Classes:
C08J3/12; A61K47/36; C08B30/06; C08B30/12
Domestic Patent References:
| WO1996004315A1 | 1996-02-15 | |||
| WO2011124656A1 | 2011-10-13 | |||
| WO2009103514A1 | 2009-08-27 | |||
| WO2009013346A1 | 2009-01-29 |
Foreign References:
| JPS5399340A | 1978-08-30 | |||
| JPS49110819A | 1974-10-22 | |||
| JP2008032767A | 2008-02-14 | |||
| JPS5827774B2 | 1983-06-11 |
Other References:
"Dictionary of Chemistry 1", 31 July 1962, KYORITSU SHUPPAN CO., LTD., pages: 428
"Handbook of Starch Science", 1977, ASAKURA PUBLISHING CO., LTD., pages: 242
"Handbook of Starch Science", 1977, ASAKURA PUBLISHING CO., LTD., pages: 242
Attorney, Agent or Firm:
IIDA, Akio et al. (JP)
Akio Iida (JP)
Akio Iida (JP)
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