Title:
METHOD FOR PRODUCING STEVIOL GLYCOSIDE
Document Type and Number:
WIPO Patent Application WO/2013/146555
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing a steviol glycoside.
The present invention provides a method for producing a steviol glycoside. The present invention provides: a transformant having a steviol glycosyltransferase gene introduced therein; and a method for producing a steviol glycoside using the transformant.
Inventors:
ONO EIICHIRO (JP)
Application Number:
PCT/JP2013/058188
Publication Date:
October 03, 2013
Filing Date:
March 14, 2013
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
C12N15/09; A01H5/00; A23L1/30; A23L27/30; A61K8/60; C07H15/256; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/10; C12P19/44
Domestic Patent References:
| WO2011153378A1 | 2011-12-08 | |||
| WO2013022989A2 | 2013-02-14 |
Foreign References:
| EP1897951B1 | 2010-12-15 | |||
| JPH05255372A | 1993-10-05 | |||
| EP1897951B1 | 2010-12-15 | |||
| JP2005287403A | 2005-10-20 | |||
| US6045996A | 2000-04-04 | |||
| US5925525A | 1999-07-20 | |||
| US5858659A | 1999-01-12 |
Other References:
RICHMAN A ET AL.: "Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana", PLANT. J., vol. 41, no. 1, 2005, pages 56 - 67, XP002686584
MOHAMED AA ET AL.: "UDP-dependent glycosyltransferases involved in the biosynthesis of steviol glycosides", J. PLANT. PHYSIOL., vol. 168, no. 10, 2011, pages 1136 - 1141, XP055162148
RYOJI KASAI ET AL.: "Stevia-ha no Kanmi Diterpene Haitotai -Rebaudioside-A, -D, -E Oyobi Kanren Haitotai no Gosei Narabini Kanmi to Kagaku Kozo tono Sokan", JOURNAL OF THE CHEMICAL SOCIETY OF JAPAN, 1981, pages 726 - 735, XP009039502
BRANDLE JE ET AL.: "Steviol glycoside biosynthesis", PHYTOCHEMISTRY, vol. 68, no. 14, 2007, pages 1855 - 1863, XP022145443
MADHAV H ET AL.: "Functional and structural variation of uridine diphosphate glycosyltransferase (UGT) gene of Stevia rebaudiana-UGTSr involved in the synthesis of rebaudioside A", PLANT PHYSIOL. BIOCHEM., vol. 63, 17 December 2012 (2012-12-17), pages 245 - 253, XP055111642
BRANDLE; TELMER, PHYTOCHEMISTRY, vol. 68, 2007, pages 1855 - 1863
RICHMAN ET AL., PLANT J., vol. 41, 2005, pages 56 - 67
MIZUTANI; OHTA, ANNU. REV. PLANT BIOL., vol. 61, 2010, pages 291 - 315
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
NUC. ACIDS. RES., vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 34, 1985, pages 315
NUC. ACIDS. RES., vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
SAMBROOK; RUSSELL: "Molecular Cloning; A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR, LABORATORY PRESS
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NAIL ACAD. SCI. USA, vol. 90, 1993, pages 5873
ALTSCHUL S. F., J. MOL. BIOL., vol. 215, 1990, pages 403
MARIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 337
JUNJI INOKOSHI ET AL., BIOCHEMISTRY, vol. 64, 1992, pages 660
HUSSAIN ET AL., GENE, vol. 101, 1991, pages 149
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
J. BACTERIOLOGY, vol. 153, 1983, pages 163
"Methods in yeast genetics", 2000
"Methods in Yeast Genetics, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
HIROBUMI UCHIMIYA: "Manuals for Plant Gene Manipulation", 1990, KODANSHA SCIENTIFIC CO., LTD., pages: 27 - 31
NAGEL ET AL., MICRIBIOL. LETT., vol. 67, 1990, pages 325
GELVIN, S.B. ET AL.: "Plant Molecular Biology Manual", ACADEMIC PRESS PUBLISHERS
SAMBROOK; FRITSCH; MANIATIS: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SIEBEN V.J. ET AL., IET NANOBIOTECHNOLOGY, vol. 1, no. 3, June 2007 (2007-06-01), pages 27 - 35
See also references of EP 2832858A4
MOHAMED AA ET AL.: "UDP-dependent glycosyltransferases involved in the biosynthesis of steviol glycosides", J. PLANT. PHYSIOL., vol. 168, no. 10, 2011, pages 1136 - 1141, XP055162148
RYOJI KASAI ET AL.: "Stevia-ha no Kanmi Diterpene Haitotai -Rebaudioside-A, -D, -E Oyobi Kanren Haitotai no Gosei Narabini Kanmi to Kagaku Kozo tono Sokan", JOURNAL OF THE CHEMICAL SOCIETY OF JAPAN, 1981, pages 726 - 735, XP009039502
BRANDLE JE ET AL.: "Steviol glycoside biosynthesis", PHYTOCHEMISTRY, vol. 68, no. 14, 2007, pages 1855 - 1863, XP022145443
MADHAV H ET AL.: "Functional and structural variation of uridine diphosphate glycosyltransferase (UGT) gene of Stevia rebaudiana-UGTSr involved in the synthesis of rebaudioside A", PLANT PHYSIOL. BIOCHEM., vol. 63, 17 December 2012 (2012-12-17), pages 245 - 253, XP055111642
BRANDLE; TELMER, PHYTOCHEMISTRY, vol. 68, 2007, pages 1855 - 1863
RICHMAN ET AL., PLANT J., vol. 41, 2005, pages 56 - 67
MIZUTANI; OHTA, ANNU. REV. PLANT BIOL., vol. 61, 2010, pages 291 - 315
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
NUC. ACIDS. RES., vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 34, 1985, pages 315
NUC. ACIDS. RES., vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
SAMBROOK; RUSSELL: "Molecular Cloning; A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR, LABORATORY PRESS
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NAIL ACAD. SCI. USA, vol. 90, 1993, pages 5873
ALTSCHUL S. F., J. MOL. BIOL., vol. 215, 1990, pages 403
MARIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 337
JUNJI INOKOSHI ET AL., BIOCHEMISTRY, vol. 64, 1992, pages 660
HUSSAIN ET AL., GENE, vol. 101, 1991, pages 149
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
J. BACTERIOLOGY, vol. 153, 1983, pages 163
"Methods in yeast genetics", 2000
"Methods in Yeast Genetics, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
HIROBUMI UCHIMIYA: "Manuals for Plant Gene Manipulation", 1990, KODANSHA SCIENTIFIC CO., LTD., pages: 27 - 31
NAGEL ET AL., MICRIBIOL. LETT., vol. 67, 1990, pages 325
GELVIN, S.B. ET AL.: "Plant Molecular Biology Manual", ACADEMIC PRESS PUBLISHERS
SAMBROOK; FRITSCH; MANIATIS: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SIEBEN V.J. ET AL., IET NANOBIOTECHNOLOGY, vol. 1, no. 3, June 2007 (2007-06-01), pages 27 - 35
See also references of EP 2832858A4
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Hiroshi Kobayashi (JP)
Hiroshi Kobayashi (JP)
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