Title:
METHOD FOR PRODUCING SUBSTANTIALLY PURE D-TALITOL OR ALLITOL
Document Type and Number:
WIPO Patent Application WO/2023/063337
Kind Code:
A1
Abstract:
[Problem] To provide a method for producing substantially pure D-talitol or allitol from a mixture of D-talitol and allitol. [Solution] The present invention pertains to (a) a method that comprises a step for performing a crystallization operation for precipitating, through condensation, crystals from an aqueous solution of a mixture (A) of D-talitol and allitol, to obtain a crystal (A-1) having a higher allitol proportion as compared to prior to crystallization and a mixture liquid (A-2) having a lower allitol content and an increased D-talitol percentage content as compared to prior to crystallization, and that is for obtaining substantially pure D-talitol (B) by causing the mixture liquid (A-2) to i) pass through a chromatography column to collect a D-talitol fraction not containing allitol or to ii) be treated with a microorganism that processes allitol but does not process D-talitol to break down allitol. Alternatively, the present invention pertains to (b) a method for obtaining substantially pure D-talitol (B) by producing D-allulose from allitol through processing of an aqueous solution of a mixture (A) of D-talitol and allitol using a microorganism having the ability to produce D-allulose from allitol, and by passing the solution through a chromatography column to collect a D-talitol fraction not containing D-allulose.
Inventors:
KATO SHIRO (JP)
IZUMORI KEN (JP)
YOSHIHARA AKIHIDE (JP)
MOCHIZUKI SUSUMU (JP)
AKIMITSU KAZUYA (JP)
IZUMORI KEN (JP)
YOSHIHARA AKIHIDE (JP)
MOCHIZUKI SUSUMU (JP)
AKIMITSU KAZUYA (JP)
Application Number:
PCT/JP2022/037982
Publication Date:
April 20, 2023
Filing Date:
October 12, 2022
Export Citation:
Assignee:
UNIV KAGAWA NAT UNIV CORP (JP)
International Classes:
C12P7/18; C12N1/20; C12N9/90; C12N11/00
Domestic Patent References:
| WO2002092545A1 | 2002-11-21 | |||
| WO2008062570A1 | 2008-05-29 | |||
| WO2020096006A1 | 2020-05-14 |
Foreign References:
| JP2009207462A | 2009-09-17 | |||
| JP2010505441A | 2010-02-25 | |||
| JPH04197192A | 1992-07-16 | |||
| JPH0856659A | 1996-03-05 |
Other References:
PUSHPAKIRAN GULLAPALLI, TAKATA GORO, POONPERM WAYOON, RAO DEVENDAR, MORIMOTO KENJI, AKIMITSU KAZUYA, TAJIMA SHIGEYUKI, IZUMORI KEN: "Bioproduction of D-Psicose from Allitol with Enterobacter aerogenes IK7: A New Frontier in Rare Ketose Production", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JP, vol. 71, no. 12, 1 January 2007 (2007-01-01), JP , pages 3048 - 3054, XP055354147, ISSN: 0916-8451, DOI: 10.1271/bbb.70450
POONPERM, W. TAKATA, G. ANDO, Y. SAHACHAISAREE, V. LUMYONG, P. LUMYONG, S. IZUMORI, K.: "Efficient conversion of allitol to d-psicose by Bacillus pallidus Y25", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, vol. 103, no. 3, 1 March 2007 (2007-03-01), NL , pages 282 - 285, XP022028175, ISSN: 1389-1723, DOI: 10.1263/jbb.103.282
LU FUZHI; XU WEI; ZHANG WENLI; GUANG CUIE; MU WANMENG: "Polyol dehydrogenases: intermediate role in the bioconversion of rare sugars and alcohols", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 103, no. 16, 2 July 2019 (2019-07-02), Berlin/Heidelberg, pages 6473 - 6481, XP036847529, ISSN: 0175-7598, DOI: 10.1007/s00253-019-09980-z
POONPERM, W. TAKATA, G. ANDO, Y. SAHACHAISAREE, V. LUMYONG, P. LUMYONG, S. IZUMORI, K.: "Efficient conversion of allitol to d-psicose by Bacillus pallidus Y25", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, vol. 103, no. 3, 1 March 2007 (2007-03-01), NL , pages 282 - 285, XP022028175, ISSN: 1389-1723, DOI: 10.1263/jbb.103.282
LU FUZHI; XU WEI; ZHANG WENLI; GUANG CUIE; MU WANMENG: "Polyol dehydrogenases: intermediate role in the bioconversion of rare sugars and alcohols", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 103, no. 16, 2 July 2019 (2019-07-02), Berlin/Heidelberg, pages 6473 - 6481, XP036847529, ISSN: 0175-7598, DOI: 10.1007/s00253-019-09980-z
Attorney, Agent or Firm:
SUDO, Akinobu et al. (JP)
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