Title:
METHOD FOR PRODUCING THIOETHER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2006/038741
Kind Code:
A1
Abstract:
Disclosed is an efficient and widely-applicable method for commercially producing a thioether compound or a thiol compound which is useful as a pharmaceutical product or a production intermediate of a pharmaceutical product. Specifically disclosed is a method for producing a thioether compound represented by the general formula [I] below or a salt thereof. This method is characterized in that a compound represented by the following general formula [III]: [III] (wherein X represents a bromine atom, a chlorine atom or a trifluoromethylsulfonyloxy group, and ring A represents an aryl group or a heteroaryl ring group) or a salt thereof is reacted with a thiol compound represented by the following general formula [II]: [II] or a salt thereof in the presence of a palladium compound such as Pd2(dba)3, a base such as i-Pr2NEt and a phosphorus compound represented by the following formula [AA].
Inventors:
ITO TAKAHIRO (JP)
MASE TOSHIAKI (JP)
AKAO ATSUSHI (JP)
MASE TOSHIAKI (JP)
AKAO ATSUSHI (JP)
Application Number:
PCT/JP2005/018985
Publication Date:
April 13, 2006
Filing Date:
October 07, 2005
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
ITO TAKAHIRO (JP)
MASE TOSHIAKI (JP)
AKAO ATSUSHI (JP)
ITO TAKAHIRO (JP)
MASE TOSHIAKI (JP)
AKAO ATSUSHI (JP)
International Classes:
C07C319/18; B01J31/24; C07C319/06; C07C321/26; C07C321/28; C07C321/30; C07C323/09; C07C323/16; C07C323/20; C07C323/22; C07C323/52; C07C323/62; C07D209/08; C07D213/32; C07D213/70; C07F9/50; C07F15/00
Other References:
SCHOPFER U. AND SCHLAPBACH A.: "A general palladium-catalyzed synthesis of aromatic and heteroaromatic thioethers", TETRAHEDRON, vol. 57, no. 15, 9 April 2001 (2001-04-09), pages 3069 - 3073, XP004235135
OGAWA A. ET AL: "Highly regio- and stereocontrolled synthesis of vinyl sulfides via transition-metal-catalyzed hydrothiolation of alkynes with thiols", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 121, no. 22, 9 June 1999 (1999-06-09), pages 5108 - 5114, XP002995008
See also references of EP 1806337A4
OGAWA A. ET AL: "Highly regio- and stereocontrolled synthesis of vinyl sulfides via transition-metal-catalyzed hydrothiolation of alkynes with thiols", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 121, no. 22, 9 June 1999 (1999-06-09), pages 5108 - 5114, XP002995008
See also references of EP 1806337A4
Attorney, Agent or Firm:
BANYU PHARMACEUTICAL CO., LTD (Kudankita Chiyoda-ku, Tokyo 67, JP)
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