METHOD OF PRODUCING TIAZOFURIN AND OTHER C-NUCLEOSIDES

Title:

METHOD OF PRODUCING TIAZOFURIN AND OTHER C-NUCLEOSIDES

Document Type and Number:

WIPO Patent Application WO1999000399

Kind Code:

A9

Abstract:

C-nucleosides are synthesized by a method in which a sugar is derivatized in a single step to provide a heterocycle at the C1 position, and then the heterocycle is aromatized in another single step. In one class of preferred embodiments a cyano sugar is converted into thiocarboxamide, and subsequently condensed to form an azole ring. In a second class of preferred embodiments a cyano sugar is condensed with an amino acid to provide the azole ring. In a third class of preferred embodiments a halo sugar is condensed with a preformed heterocycle to provide the azole ring.

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Inventors:

RAMASAMY KANDASAMY (US)
BANDARU RAJANIKANTH (US)
AVERETT DEVRON (US)

Application Number:

PCT/US1998/013367

Publication Date:

April 15, 1999

Filing Date:

June 25, 1998

Export Citation:

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Assignee:

ICN PHARMACEUTICALS (US)
RAMASAMY KANDASAMY (US)
BANDARU RAJANIKANTH (US)
AVERETT DEVRON (US)

International Classes:

A61K31/427; A61P35/02; C07D417/04; C07H7/06; C07H9/02; C07H19/04; C07H1/00; C07H3/00; (IPC1-7): C07H1/00; C07H3/02

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