Title:
METHOD FOR PRODUCING TRIAZOLE DERIVATIVE ENANTIOMER (R)
Document Type and Number:
WIPO Patent Application WO/2024/014282
Kind Code:
A1
Abstract:
Provided is a method for producing a triazole derivative enantiomer (R). The method includes: a step for adding, in a solvent, a chiral molecule represented by general formula (IIa) or general formula (IIb) to a triazole derivative represented by general formula (I), and carrying out crystallization; and a step for separating a precipitated crystal and a residual liquid.
Inventors:
HAGIHARA RYUSUKE (JP)
UMENO TOMOHIRO (JP)
KARASAWA SATORU (JP)
UMENO TOMOHIRO (JP)
KARASAWA SATORU (JP)
Application Number:
PCT/JP2023/023822
Publication Date:
January 18, 2024
Filing Date:
June 27, 2023
Export Citation:
Assignee:
KUREHA CORP (JP)
International Classes:
C07D249/08; C07B57/00
Domestic Patent References:
| WO2019093522A1 | 2019-05-16 | |||
| WO2021230382A1 | 2021-11-18 |
Foreign References:
| JPH0680605A | 1994-03-22 | |||
| JPH06192236A | 1994-07-12 | |||
| JPH0710822A | 1995-01-13 | |||
| JPH10245368A | 1998-09-14 |
Other References:
YAMANAKA HIROSHI ET AL.: "Separation of optical isomers", QUARTERLY CHEMICAL REVIEW, NIHON KAGAKKAI, JP, no. 6, 1 January 1989 (1989-01-01), JP , pages 2 - 11, XP009551912, ISSN: 1342-5722
PÉTER BAGI; BENCE VARGA; ANDRÁS SZILÁGYI; KONSTANTIN KARAGHIOSOFF; MÁTYÁS CZUGLER; ELEMÉR FOGASSY; GYÖRGY KEGLEVICH: "The resolution of acyclic P‐stereogenic phosphine oxides via the formation of diastereomeric complexes: A case study on ethyl‐(2‐methylphenyl)‐phenylphosphine oxide", CHIRALITY, WILEY-LISS, NEW YORK., US, vol. 30, no. 4, 23 January 2018 (2018-01-23), US , pages 509 - 522, XP071747834, ISSN: 0899-0042, DOI: 10.1002/chir.22816
SEEBACH DIETER, PLATTNER DIETMAR A., BECK ALBERT K., WANG YAN MING, HUNZIKER DANIEL, PETTER WALTER: "On the Mechanisms of Enantioselective Reactions Using α,α,α′,α′ ‐Tetraaryl‐1,3‐dioxolane‐4,5‐dimethanol(TADDOL)‐Derived Titanates: Differences between C 2 ‐ and C 1 ‐symmetrical TADDOLs – facts, implications and generalizations", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., HOBOKEN, USA, vol. 75, no. 7, 11 November 1992 (1992-11-11), Hoboken, USA, pages 2171 - 2209, XP093129027, ISSN: 0018-019X, DOI: 10.1002/hlca.19920750704
PÉTER BAGI; BENCE VARGA; ANDRÁS SZILÁGYI; KONSTANTIN KARAGHIOSOFF; MÁTYÁS CZUGLER; ELEMÉR FOGASSY; GYÖRGY KEGLEVICH: "The resolution of acyclic P‐stereogenic phosphine oxides via the formation of diastereomeric complexes: A case study on ethyl‐(2‐methylphenyl)‐phenylphosphine oxide", CHIRALITY, WILEY-LISS, NEW YORK., US, vol. 30, no. 4, 23 January 2018 (2018-01-23), US , pages 509 - 522, XP071747834, ISSN: 0899-0042, DOI: 10.1002/chir.22816
SEEBACH DIETER, PLATTNER DIETMAR A., BECK ALBERT K., WANG YAN MING, HUNZIKER DANIEL, PETTER WALTER: "On the Mechanisms of Enantioselective Reactions Using α,α,α′,α′ ‐Tetraaryl‐1,3‐dioxolane‐4,5‐dimethanol(TADDOL)‐Derived Titanates: Differences between C 2 ‐ and C 1 ‐symmetrical TADDOLs – facts, implications and generalizations", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., HOBOKEN, USA, vol. 75, no. 7, 11 November 1992 (1992-11-11), Hoboken, USA, pages 2171 - 2209, XP093129027, ISSN: 0018-019X, DOI: 10.1002/hlca.19920750704
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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