Title:
METHOD FOR PRODUCING TRIPTOLIDE
Document Type and Number:
WIPO Patent Application WO/2011/054929
Kind Code:
A3
Abstract:
The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dedifferentiated cells of the species Tripterygium, and to the therapeutic applications of said extract.
More Like This:
Inventors:
STEWARD NICOLAS (FR)
CHOMARAT NADINE (FR)
N GUYEN NGOC THIEN (FR)
CHOMARAT NADINE (FR)
N GUYEN NGOC THIEN (FR)
Application Number:
PCT/EP2010/066916
Publication Date:
December 01, 2011
Filing Date:
November 05, 2010
Export Citation:
Assignee:
PF MEDICAMENT (FR)
STEWARD NICOLAS (FR)
CHOMARAT NADINE (FR)
N GUYEN NGOC THIEN (FR)
STEWARD NICOLAS (FR)
CHOMARAT NADINE (FR)
N GUYEN NGOC THIEN (FR)
International Classes:
C12P33/20; A61K8/49; A61K8/97; A61K31/365; A61K36/37; A61Q19/00; C07J73/00; C12N5/00; C12P17/18
Domestic Patent References:
| WO2005012507A1 | 2005-02-10 | |||
| WO1997044476A1 | 1997-11-27 | |||
| WO1998013057A1 | 1998-04-02 |
Foreign References:
| US4328309A | 1982-05-04 | |||
| JPS572699A | 1982-01-08 |
Other References:
KUTNEY JAMES P ET AL: "Cytotoxic diterpenes triptolide, tripdiolide, and cytotoxic triterpenes from tissue cultures of Tripterygium wilfordii", CANADIAN JOURNAL OF CHEMISTRY, NRC RESEARCH PRESS, CA, vol. 59, no. 17, 1 January 1981 (1981-01-01), pages 2677 - 2683, XP002592559, ISSN: 0008-4042, DOI: 10.1139/V81-385
KUTNEY, J.P., HAN, K.: "Studies with plant-cell cultures of the Chinese herbal plant, Tripterygium wilfordii. Isolation and characterization of diterpenes", RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS / JOURNAL OF THE ROYAL NETHERLANDS, vol. 115, no. 1, 1996, pages 77 - 93, XP008124425
BAJAJ Y.P.S. (ED.): "Biotechnology in argriculture and forestry", vol. 28, part Medicinal and aromatic plants VII 1994, SPRINGER-VERLAG, BERLIN, GERMANY, article TAKAYAMA S.: "Tripterygium wilfordii: In vitro culture and the production of the anticancer compounds tripdiolide and triptolide (Chapter XXVIII)", pages: 457 - 468, XP008124468
SAMIJA, MD: "Enhanced yield of medicinal products from Tripterygium cell cultures (Thesis)", THE UNIVERSITY OF BRITISH COLUMBIA, UBC LIBRARY, VANCOUVER, CANADA, 1 February 1992 (1992-02-01), pages I - iv, 26-51,67-88,116,137-139, XP002592561, Retrieved from the Internet [retrieved on 20100719]
KUTNEY J P ET AL: "Cultivation of Tripterygium wilfordii Tissue Cultures for the Production of the Cytotoxic Diterpene Tripdiolide.", PLANTA MEDICA, vol. 48, no. 7, July 1983 (1983-07-01), pages 158 - 163, XP008124443, ISSN: 0032-0943
KUTNEY J P ET AL: "Studies with Plant Cell Cultures of the Chinese Herbal Plant, Tripterygium wilfordii. Synthesis and Biotransformation of Diterpene Analogues", HETEROCYCLES, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 44, no. 1, 1 January 1997 (1997-01-01), pages 95 - 104, XP008124404, ISSN: 0385-5414, DOI: 10.3987/COM-96-S25
DATABASE WPI Week 200914, Derwent World Patents Index; AN 2009-B11376, XP002592589
DATABASE WPI Week 200415, Derwent World Patents Index; AN 2004-144403, XP002592590
DATABASE WPI Week 198308, Derwent World Patents Index; AN 1983-18319K, XP002592591
DUJACK L W ET AL: "ANTI NEOPLASTIC DI TERPENES IN TRIPTERYGIUM-WILFORDII TISSUE CULTURE THE EFFECTS OF PRECURSORS ON DI TERPENE PRODUCTION", IN VITRO; 31ST ANNUAL MEETING OF THE TISSUE CULTURE ASSOCIATION, ST. LOUIS, MO., USA, JUNE 1-5, 1980, TISSUE CULTURE ASSOCIATION, US, vol. 16, no. 3, 1 March 1980 (1980-03-01), pages 216, XP008124540, ISSN: 0073-5655, [retrieved on 20070501], DOI: 10.1007/BF02616149
KUTNEY J P ET AL: "Studies with tissue cultures of the Chinese herbal plant, Tripterygium wilfordii. Isolation of metabolites of interest in rheumatoid arthritis, immunosuppression, and male contraceptive activity", CANADIAN JOURNAL OF CHEMISTRY, vol. 70, no. 5, 1992, pages 1455 - 1480, XP002650436, ISSN: 0008-4042
DHARMANANDA S: "TRIPTERYGIUM", INSTITUTE FOR TRADITIONAL MEDICINE, PORTLAND, OREGON, USA, April 1996 (1996-04-01), XP002650437, Retrieved from the Internet [retrieved on 20110714]
TAO XUELIAN ET AL: "Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F", ARTHRITIS & RHEUMATISM, JOHN WILEY & SONS, INC, US, vol. 58, no. 6, 1 June 2008 (2008-06-01), pages 1774 - 1783, XP002591440, ISSN: 0004-3591, [retrieved on 20080531], DOI: 10.1002/ART.23513
XU W Y ET AL: "Tripterygium in dermatologic therapy", INTERNATIONAL JOURNAL OF DERMATOLOGY, vol. 24, no. 3, April 1985 (1985-04-01), pages 152 - 157, XP002650438, ISSN: 0011-9059
TAO X ET AL: "The chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F", RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, vol. 26, no. 1, 1 February 2000 (2000-02-01), pages 29 - 50, XP000961355, ISSN: 0889-857X, DOI: 10.1016/S0889-857X(05)70118-6
KUTNEY, J.P., HAN, K.: "Studies with plant-cell cultures of the Chinese herbal plant, Tripterygium wilfordii. Isolation and characterization of diterpenes", RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS / JOURNAL OF THE ROYAL NETHERLANDS, vol. 115, no. 1, 1996, pages 77 - 93, XP008124425
BAJAJ Y.P.S. (ED.): "Biotechnology in argriculture and forestry", vol. 28, part Medicinal and aromatic plants VII 1994, SPRINGER-VERLAG, BERLIN, GERMANY, article TAKAYAMA S.: "Tripterygium wilfordii: In vitro culture and the production of the anticancer compounds tripdiolide and triptolide (Chapter XXVIII)", pages: 457 - 468, XP008124468
SAMIJA, MD: "Enhanced yield of medicinal products from Tripterygium cell cultures (Thesis)", THE UNIVERSITY OF BRITISH COLUMBIA, UBC LIBRARY, VANCOUVER, CANADA, 1 February 1992 (1992-02-01), pages I - iv, 26-51,67-88,116,137-139, XP002592561, Retrieved from the Internet
KUTNEY J P ET AL: "Cultivation of Tripterygium wilfordii Tissue Cultures for the Production of the Cytotoxic Diterpene Tripdiolide.", PLANTA MEDICA, vol. 48, no. 7, July 1983 (1983-07-01), pages 158 - 163, XP008124443, ISSN: 0032-0943
KUTNEY J P ET AL: "Studies with Plant Cell Cultures of the Chinese Herbal Plant, Tripterygium wilfordii. Synthesis and Biotransformation of Diterpene Analogues", HETEROCYCLES, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 44, no. 1, 1 January 1997 (1997-01-01), pages 95 - 104, XP008124404, ISSN: 0385-5414, DOI: 10.3987/COM-96-S25
DATABASE WPI Week 200914, Derwent World Patents Index; AN 2009-B11376, XP002592589
DATABASE WPI Week 200415, Derwent World Patents Index; AN 2004-144403, XP002592590
DATABASE WPI Week 198308, Derwent World Patents Index; AN 1983-18319K, XP002592591
DUJACK L W ET AL: "ANTI NEOPLASTIC DI TERPENES IN TRIPTERYGIUM-WILFORDII TISSUE CULTURE THE EFFECTS OF PRECURSORS ON DI TERPENE PRODUCTION", IN VITRO; 31ST ANNUAL MEETING OF THE TISSUE CULTURE ASSOCIATION, ST. LOUIS, MO., USA, JUNE 1-5, 1980, TISSUE CULTURE ASSOCIATION, US, vol. 16, no. 3, 1 March 1980 (1980-03-01), pages 216, XP008124540, ISSN: 0073-5655, [retrieved on 20070501], DOI: 10.1007/BF02616149
KUTNEY J P ET AL: "Studies with tissue cultures of the Chinese herbal plant, Tripterygium wilfordii. Isolation of metabolites of interest in rheumatoid arthritis, immunosuppression, and male contraceptive activity", CANADIAN JOURNAL OF CHEMISTRY, vol. 70, no. 5, 1992, pages 1455 - 1480, XP002650436, ISSN: 0008-4042
DHARMANANDA S: "TRIPTERYGIUM", INSTITUTE FOR TRADITIONAL MEDICINE, PORTLAND, OREGON, USA, April 1996 (1996-04-01), XP002650437, Retrieved from the Internet
TAO XUELIAN ET AL: "Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F", ARTHRITIS & RHEUMATISM, JOHN WILEY & SONS, INC, US, vol. 58, no. 6, 1 June 2008 (2008-06-01), pages 1774 - 1783, XP002591440, ISSN: 0004-3591, [retrieved on 20080531], DOI: 10.1002/ART.23513
XU W Y ET AL: "Tripterygium in dermatologic therapy", INTERNATIONAL JOURNAL OF DERMATOLOGY, vol. 24, no. 3, April 1985 (1985-04-01), pages 152 - 157, XP002650438, ISSN: 0011-9059
TAO X ET AL: "The chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F", RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, vol. 26, no. 1, 1 February 2000 (2000-02-01), pages 29 - 50, XP000961355, ISSN: 0889-857X, DOI: 10.1016/S0889-857X(05)70118-6
Attorney, Agent or Firm:
AHNER, Francis (20 rue de Chazelles, Paris Cedex 17, FR)
Download PDF:
Previous Patent: METHOD FOR PRODUCING NITRIC ACID BY MEANS OF A LOAD-CONTROLLABLE PRODUCTION SYSTEM
Next Patent: PHARMACEUTICAL SOLID DOSAGE FORM
Next Patent: PHARMACEUTICAL SOLID DOSAGE FORM