Title:
METHOD FOR PRODUCING UNSATURATED AMINOCARBOXYLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/058577
Kind Code:
A1
Abstract:
Disclosed is a method for producing an unsaturated aminocarboxylic acid derivative, which is useful as a pharmaceutical raw material, at low cost. Specifically, an unsaturated aminocarboxylic acid derivative is produced by hydrolyzing an unsaturated aminonitrile derivative. The unsaturated aminonitrile derivative can be obtained, for example, by reacting an unsaturated aldehyde with a cyanogen compound and an ammonia compound. In addition, an optically active unsaturated aminocarboxylic acid derivative can be easily obtained from the unsaturated aminocarboxylic acid derivative via an unsaturated N-acylaminocarboxylic acid derivative. Consequently, an optically active unsaturated aminocarboxylic acid derivative can be easily produced at low cost.
Inventors:
OKURO KAZUMI (JP)
SAKA YASUHIRO (JP)
SAKA YASUHIRO (JP)
Application Number:
PCT/JP2009/006219
Publication Date:
May 27, 2010
Filing Date:
November 19, 2009
Export Citation:
Assignee:
KANEKA CORP (JP)
OKURO KAZUMI (JP)
SAKA YASUHIRO (JP)
OKURO KAZUMI (JP)
SAKA YASUHIRO (JP)
International Classes:
C07C227/26; C07C229/30; C07C231/02; C07C231/06; C07C233/47; C07C237/16; C07C253/08; C07C255/30; C12P41/00
Foreign References:
| JP2007510002A | 2007-04-19 | |||
| JPS62103056A | 1987-05-13 | |||
| US5534542A | 1996-07-09 |
Other References:
XIAO-JUN WANG ET AL.: "Efficient Synthesis of (S)-2-(Cyclopentyloxycarbonyl)-amino-8-nonenoic Acid: Key Building Block for BILN 2061, an HCV NS3 Protease Inhibitor", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 11, 2007, pages 60 - 63
LARISSA B. WOLF ET AL.: "A Biocatalytic Route to Enantiomerically Pure Unsaturated alpha-H-alpha-Amino Acids", ADV. SYNTH. CATAL., vol. 343, no. 6-7, 2001, pages 662 - 674
LARISSA B. WOLF ET AL.: "A Biocatalytic Route to Enantiomerically Pure Unsaturated alpha-H-alpha-Amino Acids", ADV. SYNTH. CATAL., vol. 343, no. 6-7, 2001, pages 662 - 674
Attorney, Agent or Firm:
KANEKA CORPORATION (JP)
KANEKA Co. (JP)
KANEKA Co. (JP)
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