Title:
METHOD FOR PRODUCING UROLITHINS
Document Type and Number:
WIPO Patent Application WO/2019/130681
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for removing the hydroxyl group at the 8-position of a urolithin to produce a different urolithin. The present invention solves this problem by means of a method for producing a second urolithin that includes step (a): a step in which, in a solution containing a first urolithin, microorganisms having the capacity to generate the second urolithin from the first urolithin are caused to generate the second urolithin from the first urolithin.
Inventors:
NAKAJIMA TAKANORI (JP)
YAMAMOTO HIROAKI (JP)
YAMAMOTO HIROAKI (JP)
Application Number:
PCT/JP2018/034916
Publication Date:
July 04, 2019
Filing Date:
September 20, 2018
Export Citation:
Assignee:
DAICEL CORP (JP)
International Classes:
A23L33/105; C12P17/06; C12R1/01
Domestic Patent References:
| WO2014147280A1 | 2014-09-25 | |||
| WO2014147280A1 | 2014-09-25 |
Foreign References:
| JP2017192331A | 2017-10-26 |
Other References:
SELMA, M. V. ET AL.: "Description of urolithin production capacity from ellagic acid of two human intestinal gordonibacter species", FOOD & FUNCTION, vol. 5, no. 8, 8 May 2014 (2014-05-08), pages 1779 - 1784, XP055509687
PUKALL, R. ET AL.: "Complete genome sequence of slackia heliotrinireducens type strain (RHS 1T", STANDARDS IN GENOMIC SCIENCES, vol. 1, no. 3, 2009, pages 234 - 241, XP055622414, ISSN: 1944-3277, DOI: 10.4056/sigs.37633
AKIKO TAKAGAKI: FUMIO NANJO : "Biotransformation of (-)- epigallocatechin and (-)-gallocatechin by intestinal bacteria involved in isoflavone metabolism", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 2, 1 January 2015 (2015-01-01), pages 325 - 330, XP055623059, ISBN: 0918-6158, DOI: 10.1248/bpb.b14-00646
TAKAGAKI, A. ET AL.: "Biotransformation of- epicatechin, (+)-epicatechin, (-)-catechin, and (+)-catechin by intestinal bacteria involved in isoflavone metabolism", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 80, no. 1, 27 August 2015 (2015-08-27), pages 199 - 202, XP055622421, ISSN: 0916-8451, DOI: 10.1080/09168451.2015.1079480
JIN, J. S. ET AL.: "Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol.", INT. J. SYST. EVOL. MICROBIOL., vol. 60, no. 8, August 2010 (2010-08-01), pages 1721 - 1724, XP055163035, DOI: 10.1099/ijs.0.016774-0
LI, Z. ET AL.: "Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers.", FOOD FUNCT., vol. 6, no. 8, 2015, pages 2487 - 2495, XP055622425, ISSN: 2042-6496, DOI: 10.1039/C5FO00669D
GARCIA-VILLALBA, R. ET AL.: "Time course production of urolithins from ellagic acid by human gut microbiota.", J. AGRIC. FOOD CHEM., vol. 61, no. 37, 18 September 2013 (2013-09-18), pages 8797 - 8806, XP055509684, DOI: 10.1021/jf402498b
J. AGRIC. FOOD CHEM., vol. 56, 2008, pages 393 - 400
MOL. NUTR. FOOD RES., vol. 58, 2014, pages 1199 - 1211
BIOSCI. BIOTECHNOL. BIOCHEM., vol. 76, 2012, pages 395 - 399
J. AGRIC. FOOD CHEM., vol. 60, 2012, pages 8866 - 8876
MOL. NUTR. FOOD RES., vol. 55, 2011, pages S35 - S43
NATURE MEDICINE, vol. 22, 2016, pages 879 - 888
FOOD FUNC., vol. 5, no. 8, 2014, pages 1779 - 1784
PUKALL, R. ET AL.: "Complete genome sequence of slackia heliotrinireducens type strain (RHS 1T", STANDARDS IN GENOMIC SCIENCES, vol. 1, no. 3, 2009, pages 234 - 241, XP055622414, ISSN: 1944-3277, DOI: 10.4056/sigs.37633
AKIKO TAKAGAKI: FUMIO NANJO : "Biotransformation of (-)- epigallocatechin and (-)-gallocatechin by intestinal bacteria involved in isoflavone metabolism", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 2, 1 January 2015 (2015-01-01), pages 325 - 330, XP055623059, ISBN: 0918-6158, DOI: 10.1248/bpb.b14-00646
TAKAGAKI, A. ET AL.: "Biotransformation of- epicatechin, (+)-epicatechin, (-)-catechin, and (+)-catechin by intestinal bacteria involved in isoflavone metabolism", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 80, no. 1, 27 August 2015 (2015-08-27), pages 199 - 202, XP055622421, ISSN: 0916-8451, DOI: 10.1080/09168451.2015.1079480
JIN, J. S. ET AL.: "Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol.", INT. J. SYST. EVOL. MICROBIOL., vol. 60, no. 8, August 2010 (2010-08-01), pages 1721 - 1724, XP055163035, DOI: 10.1099/ijs.0.016774-0
LI, Z. ET AL.: "Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers.", FOOD FUNCT., vol. 6, no. 8, 2015, pages 2487 - 2495, XP055622425, ISSN: 2042-6496, DOI: 10.1039/C5FO00669D
GARCIA-VILLALBA, R. ET AL.: "Time course production of urolithins from ellagic acid by human gut microbiota.", J. AGRIC. FOOD CHEM., vol. 61, no. 37, 18 September 2013 (2013-09-18), pages 8797 - 8806, XP055509684, DOI: 10.1021/jf402498b
J. AGRIC. FOOD CHEM., vol. 56, 2008, pages 393 - 400
MOL. NUTR. FOOD RES., vol. 58, 2014, pages 1199 - 1211
BIOSCI. BIOTECHNOL. BIOCHEM., vol. 76, 2012, pages 395 - 399
J. AGRIC. FOOD CHEM., vol. 60, 2012, pages 8866 - 8876
MOL. NUTR. FOOD RES., vol. 55, 2011, pages S35 - S43
NATURE MEDICINE, vol. 22, 2016, pages 879 - 888
FOOD FUNC., vol. 5, no. 8, 2014, pages 1779 - 1784
Attorney, Agent or Firm:
NIWA, Takeshi et al. (JP)
Download PDF:
Previous Patent: AQUATIC AIR CUSHION VEHICLE FOR CHEMICAL SPRAYING
Next Patent: SHOCK ABSORBER AND SOLENOID
Next Patent: SHOCK ABSORBER AND SOLENOID