Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR PRODUCING ZALTOPROFEN AND DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/161842
Kind Code:
A1
Abstract:
The invention pertains to a method for producing zaltoprofen or a zaltoprofen derivative by an intramolecular cyclization reaction of the Friedel-Crafts reaction type, wherein zaltoprofen or a zaltoprofen derivative is produced at an industrially usable yield, simply, economically, and on an industrial scale at adequate purity for use as a pharmaceutical active ingredient without generating detectable amounts of dimer or other such impurities, using polyphosphoric acid in a quantity of 6.5 times or less the uncyclized raw material compound as a condensing agent. Specifically, the invention pertains to a method for producing zaltoprofen or a zaltoprofen derivative by cyclization of an uncyclized raw material compound in the presence of one or more organic solvents selected from the group consisting of 1,1,2-trichloroethene, methyl cyclohexane, cyclohexane, n-heptane, and the like.

Inventors:
TENDO ATSUSHI (JP)
Application Number:
PCT/JP2013/061974
Publication Date:
October 31, 2013
Filing Date:
April 24, 2013
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
NIPPON CHEMIPHAR CO (JP)
International Classes:
C07D337/14; A61K31/38; A61P29/00
Foreign References:
JP2005289949A2005-10-20
JP2005247778A2005-09-15
JPS61251682A1986-11-08
JPS57171991A1982-10-22
JP2005289949A2005-10-20
JPS57171991A1982-10-22
JP2006273731A2006-10-12
JP2006290753A2006-10-26
JPS5553282A1980-04-18
JPS57106678A1982-07-02
JPS61251682A1986-11-08
JPS62108877A1987-05-20
JPS62292780A1987-12-19
JPH0899953A1996-04-16
JP2005247778A2005-09-15
JP2006160766A2006-06-22
Other References:
See also references of EP 2842952A4
PHARM TECH JAPAN, vol. 17, no. 12, 2001, pages 27 - 38
Attorney, Agent or Firm:
CHIGUSA, Shinichi et al. (JP)
1000 Shin-ichi Kusa (JP)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: DEVICE, METHOD AND PROGRAM FOR FORMAT-PRESERVING ENCRYPTION, AND DEVICE, METHOD AND PROGRAM FOR DECR...

Next Patent: LIGHT-DIFFUSING RESIN COMPOSITION AND PART MOLDED USING SAME