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Title:
A METHOD OF PRODUCTION OF 2,4-DIHYDROXYBUTYRIC ACID
Document Type and Number:
WIPO Patent Application WO/2013/160762
Kind Code:
A3
Abstract:
The present invention deals with a method for the preparation of 2,4- dihydroxybutyric acid (2,4-DHB) comprising the successive steps of converting malate, succinyl-CoA and/or glyoxylate into malyl-CoA, converting malyl-CoA previously obtained into malate-4-semialdehyde, and converting malate-4- semialdehyde into 2,4-DHB using a DHB dehydrogenase.

Inventors:
WALTHER THOMAS (FR)
DRESSAIRE CLEMENTINE (FR)
CORDIER HELENE (FR)
FRANCOIS JEAN-MARIE (FR)
Application Number:
PCT/IB2013/001071
Publication Date:
January 23, 2014
Filing Date:
April 25, 2013
Export Citation:
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Assignee:
ADISSEO FRANCE SAS (FR)
International Classes:
C12P7/42; C12N9/00; C12N9/02; C12N9/04; C12N9/10; C12N9/88; C07C59/10
Domestic Patent References:
WO2008046328A12008-04-24
WO2012056318A12012-05-03
Foreign References:
EP1167534A22002-01-02
DE102006025821A12007-12-06
US20110045575A12011-02-24
Other References:
GORDON FORD ET AL: "Characterization of Ypr1p fromSaccharomyces cerevisiae as a 2-methylbutyraldehyde reductase", YEAST, vol. 19, no. 12, 15 September 2002 (2002-09-15), pages 1087 - 1096, XP055047677, ISSN: 0749-503X, DOI: 10.1002/yea.899
D. KOCKELKORN ET AL: "Malonic Semialdehyde Reductase, Succinic Semialdehyde Reductase, and Succinyl-Coenzyme A Reductase from Metallosphaera sedula: Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Sulfolobales", JOURNAL OF BACTERIOLOGY, vol. 191, no. 20, 14 August 2009 (2009-08-14), pages 6352 - 6362, XP055021051, ISSN: 0021-9193, DOI: 10.1128/JB.00794-09
Attorney, Agent or Firm:
CABINET GERMAIN & MAUREAU et al. (Lyon Cedex 06, FR)
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