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Title:
METHOD FOR THE PRODUCTION OF COLLAGEN PROTEINS DERIVED FROM MARINE SPONGES AND AN ORGANISM ABLE TO PRODUCE SAID PROTEINS
Document Type and Number:
WIPO Patent Application WO/2014/170460
Kind Code:
A3
Abstract:
A method for the production of recombinant marine sponge collagen proteins, which method comprises introduction and expression of at least one nucleotide sequence coding for a primary polypeptide chain of marine sponge collagen proteins, and at least one nucleotide sequence coding for an enzymatic protein or at least one subunit thereof involved in the posttranslational modifications, such as hydroxylation, of said collagen proteins, in a host organism.

Inventors:
POZZOLINI MARINA (IT)
BENATTI UMBERTO (IT)
MUSSINO FRANCESCA (IT)
SCARFI SONIA (IT)
BERILLI VALENTINA (IT)
SALIS ANNALISA (IT)
DAMONTE GIANLUCA (IT)
GIOVINE MARCO (IT)
Application Number:
PCT/EP2014/057966
Publication Date:
December 31, 2014
Filing Date:
April 17, 2014
Export Citation:
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Assignee:
UNIV DEGLI STUDI GENOVA (IT)
International Classes:
A61L27/24; C07K14/00; C12N15/81
Foreign References:
EP1787995A12007-05-23
US20030032601A12003-02-13
Other References:
DATABASE EMBL [online] 6 August 2008 (2008-08-06), "Chondrosia reniformis nonfibrillar collagen mRNA, complete cds.", XP002715173, retrieved from EBI accession no. EM_STD:DQ874470 Database accession no. DQ874470
SWATSCHEK D ET AL: "Marine sponge collagen: isolation, characterization and effects on the skin parameters surface-pH, moisture and sebum", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 53, no. 1, 1 January 2002 (2002-01-01), pages 107 - 113, XP004331337, ISSN: 0939-6411, DOI: 10.1016/S0939-6411(01)00192-8
MARINA POZZOLINI ET AL: "Molecular Characterization of a Nonfibrillar Collagen from the Marine SpongeNardo 1847 and Positive Effects of Soluble Silicates on Its Expression", MARINE BIOTECHNOLOGY, SPRINGER-VERLAG, NE, vol. 14, no. 3, 10 November 2011 (2011-11-10), pages 281 - 293, XP035039502, ISSN: 1436-2236, DOI: 10.1007/S10126-011-9415-2
Attorney, Agent or Firm:
KARAGHIOSOFF, GIORGIO A. (Via F. Baracca 1R, Savona, IT)
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