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Title:
METHOD FOR PRODUCTION OF MODEL ANIMAL FOR MENTAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2012/098645
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing a model animal for mental diseases using a non-human primate. The present invention provides a method for producing a model animal for mental diseases using a non-human primate, which comprises the following steps: (a) a step of preparing a pregnant non-human primate; (b) a step of activating immunity of the primate during the organ development stage of a fetus of the primate; and (c) a step of allowing the primate to get birth. A born offspring is a model animal for mental diseases. The present invention also provides a model animal for metal diseases, which is produced by the method. The present invention further provides a method for screening for an anti-mental-disease agent using a model animal for mental diseases which is produced by the method.

Inventors:
OH-NISHI Arata (4-9-1Anagawa, Inage-k, Chiba-shi Chiba 55, 〒2638555, JP)
大西新 (〒55 千葉県千葉市稲毛区穴川四丁目9番1号 独立行政法人放射線医学総合研究所内 Chiba, 〒2638555, JP)
MINAMIMOTO Takafumi (4-9-1Anagawa, Inage-k, Chiba-shi Chiba 55, 〒2638555, JP)
南本敬史 (〒55 千葉県千葉市稲毛区穴川四丁目9番1号 独立行政法人放射線医学総合研究所内 Chiba, 〒2638555, JP)
NAGAI Yuji (4-9-1Anagawa, Inage-k, Chiba-shi Chiba 55, 〒2638555, JP)
永井裕司 (〒55 千葉県千葉市稲毛区穴川四丁目9番1号 独立行政法人放射線医学総合研究所内 Chiba, 〒2638555, JP)
Application Number:
JP2011/050757
Publication Date:
July 26, 2012
Filing Date:
January 18, 2011
Export Citation:
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Assignee:
NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES (4-9-1, Anagawa Inage-k, Chiba-shi Chiba 55, 〒2638555, JP)
独立行政法人放射線医学総合研究所 (〒55 千葉県千葉市稲毛区穴川四丁目9番1号 Chiba, 〒2638555, JP)
A SCHOOL JURIDICAL PERSON FUJITA EDUCATIONAL INSTITUTION (1-98 Dengakugakubo, Kutsukake-cho Toyoake-shi Aichi, 92, 〒4701192, JP)
学校法人 藤田学園 (〒92 愛知県豊明市沓掛町田楽ヶ窪1番地98 Aichi, 〒4701192, JP)
OH-NISHI Arata (4-9-1Anagawa, Inage-k, Chiba-shi Chiba 55, 〒2638555, JP)
大西新 (〒55 千葉県千葉市稲毛区穴川四丁目9番1号 独立行政法人放射線医学総合研究所内 Chiba, 〒2638555, JP)
MINAMIMOTO Takafumi (4-9-1Anagawa, Inage-k, Chiba-shi Chiba 55, 〒2638555, JP)
南本敬史 (〒55 千葉県千葉市稲毛区穴川四丁目9番1号 独立行政法人放射線医学総合研究所内 Chiba, 〒2638555, JP)
International Classes:
A01K67/027; A61P25/00; G01N33/15; G01N33/50
Other References:
MEYER U ET AL.: 'In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders.' NEUROSCI. BEHAV. REV. vol. 33, 2009, pages 1061 - 1079
MAO CV ET AL.: 'A primate model of schizophrenia using chronic PCP treatment.' REV. NEUROSCI. vol. 19, 2008, pages 83 - 89
FATEMI SH ET AL.: 'Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice.' MOL. PHYCHIATRY vol. 4, 1999, pages 145 - 154
Attorney, Agent or Firm:
ISHIKAWA Toru (ORION I.P.O, Fuji Bldg. 2nd. Floor 24-12, Kanumadai, 2-Chome, Chuo-k, Sagamihara-Shi Kanagawa 33, 〒2520233, JP)
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Claims: