Title:
METHOD FOR THE PRODUCTION OF PENTOPYRANOSYL NUCLEOSIDES
Document Type and Number:
WIPO Patent Application WO2002072595
Kind Code:
A3
Abstract:
The invention relates to an improved method for the production of pentopyranosyl nucleosides, in which a significant improvement and simplification of the method steps described in DE-A-19741715 can be achieved. According to the invention, a migration of the 2' acyl protecting group, from the 2' position to the 3' position of the pentopyranoside can be achieved by the application of a catalyst of formula (IVa) or (IVb), where A = -CH2-, -NR<20>-,R<20>, H, optionally substituted alkyl, cycloalkyl, aryl or aralkyl, D = a group of formula CmH2m-, m = a whole number from 1 to 6, R<18>, R<19> and R<24> independently = H, optionally substituted alkyl, cycloalkyl, aryl or aralkyl, or R<18> and R<19> together represent a -CoH2o- group, where o = a whole number from 2 to 4 and R<21> = a NR<22>R<23> group, where R<22> and R<23> independently = H, optionally substituted alkyl, cycloalkyl, aryl or aralkyl.
Inventors:
KRETZSCHMAR GERHARD (DE)
Application Number:
PCT/EP2002/002536
Publication Date:
January 23, 2003
Filing Date:
March 07, 2002
Export Citation:
Assignee:
NANOGEN RECOGNOMICS GMBH (DE)
KRETZSCHMAR GERHARD (DE)
KRETZSCHMAR GERHARD (DE)
International Classes:
C07H19/06; C07H19/16; (IPC1-7): C07H19/06; C07H19/16
Foreign References:
| DE19741715A1 | 1999-03-25 | |||
| DE19815901A1 | 1999-10-14 |
Other References:
ESCHENMOSER ET AL: "147. Why pentose- and not hexose-nucleic acids?", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA. BASEL, CH, vol. 76, 1993, pages 2161 - 2183, XP002094190, ISSN: 0018-019X
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