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Title:
METHOD FOR PROMOTING FERMENTATION THROUGH LOSS OF FUNCTION OF VACUOLAR TRANSPORTER CHAPERONE COMPLEX OF YEAST
Document Type and Number:
WIPO Patent Application WO/2017/138489
Kind Code:
A1
Abstract:
The present invention pertains to a method for enhancing the fermentation capacity and ethanol yield of yeast. Specifically, the present invention pertains to: a method for enhancing the fermentation capacity of yeast that involves causing the decrease or loss of the vacuolar transporter chaperone complex (VTC complex) function in yeast; a fermentation product production method using yeast that involves carrying out alcoholic fermentation in conditions wherein the VTC complex function in the yeast is decreased or lost; a fermentation yeast preparation method that involves causing the decrease or loss of the VTC complex function in yeast by introducing a genetic mutation; yeast wherein the VTC complex function has been decreased or lost due to genetic mutation; and a screening method for drugs that enhance the fermentation capacity of yeast.

Inventors:
WATANABE, Daisuke (8916-5 Takayama-cho, Ikoma-sh, Nara 92, 〒6300192, JP)
TAKAGI, Kenichi (8916-5 Takayama-cho, Ikoma-sh, Nara 92, 〒6300192, JP)
TAKAGI, Hiroshi (8916-5 Takayama-cho, Ikoma-sh, Nara 92, 〒6300192, JP)
Application Number:
JP2017/004212
Publication Date:
August 17, 2017
Filing Date:
February 06, 2017
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY (8916-5, Takayama-cho Ikoma-sh, Nara 92, 〒6300192, JP)
International Classes:
C12N15/09; C12N1/19; C12P7/06; A21D8/04; C12C11/02; C12G3/02
Foreign References:
JP2014076046A2014-05-01
JP2006280268A2006-10-19
Other References:
MULLER, OLIVER ET AL.: "The Vtc proteins in vacuole fusion: coupling NSF activity to VO trans-complex formation", THE EMBO JOURNAL, vol. 21, no. 3, 2002, pages 259 - 269, XP055408167
MULLER, OLIVER ET AL.: "Role of the Vtc proteins in V-ATPase stability and membrane trafficking", JOURNAL OF CELL SCIENCE, vol. 116, 2003, pages 1107 - 1115, XP055408169
NELSON, NATHAN ET AL.: "The Cellular Biology of Protein-Motive Force Generation by V-ATPase", THE JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 203, 2000, pages 89 - 95, XP055408175
COHEN, ADIEL ET AL.: "A Novel Family of Yeast Chaperons Involved in the Distribution of V- ATPase and Other Membrane Proteins", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 38, 1999, pages 26885 - 26893, XP055408179
UTTENWEILER, ANDREAS ET AL.: "The Vacuolar Transporter Chaperone (VTC) Complex is Required for Microautophagy", MOLECULAR BIOLOFY OF THE CELL, vol. 18, 2007, pages 166 - 175, XP055408180
Attorney, Agent or Firm:
SHOJI, Takashi et al. (#307, Miyuki Bldg. 5-6-13, Nishinakajima, Yodogawa-ku, Osaka-sh, Osaka 11, 〒5320011, JP)
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