Title:
METHOD FOR PROMOTING GENERATION OF STEM CELL-DERIVED EXOSOME BY USING THROMBIN
Document Type and Number:
WIPO Patent Application WO/2015/088288
Kind Code:
A1
Abstract:
The present invention relates to a method for promoting the generation of a stem cell-derived exosome by using thrombin. The method according to the present invention has a remarkable effect of promoting the generation of a stem cell-derived exosome, and thus an exosome can be effectively obtained thereby compared with a conventional method, and the method can be useful for related research.
Inventors:
CHANG YUN SIL (KR)
PARK WON SOON (KR)
SUNG DONG KYUNG (KR)
AHN SO YOON (KR)
PARK WON SOON (KR)
SUNG DONG KYUNG (KR)
AHN SO YOON (KR)
Application Number:
PCT/KR2014/012291
Publication Date:
June 18, 2015
Filing Date:
December 12, 2014
Export Citation:
Assignee:
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
A61K35/44; A61K35/12; A61K35/28; A61P25/00
Domestic Patent References:
| WO2013102219A1 | 2013-07-04 |
Foreign References:
| KR20050088118A | 2005-09-01 | |||
| KR20100116812A | 2010-11-02 | |||
| KR20080036594A | 2008-04-28 |
Other References:
VOGL, M. ET AL.: "Can Thrombin-activated Platelet Releasate Compensate the Age-induced Decrease in Cell Proliferation of MSC?", JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 31, no. 11, 9 July 2013 (2013-07-09), pages 1786 - 1795, XP055349279
CHEN, T. S. ET AL.: "Enabling a Robust Scalable Manufacturing Process for Therapeutic Exosomes through Oncogenic Immortalization of Human ESC-derived MSCs", J. TRANSL. MED., vol. 9, no. 47, 2011, pages 1 - 10, XP021097952
CHEN, T. S. ET AL.: "Enabling a Robust Scalable Manufacturing Process for Therapeutic Exosomes through Oncogenic Immortalization of Human ESC-derived MSCs", J. TRANSL. MED., vol. 9, no. 47, 2011, pages 1 - 10, XP021097952
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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