Title:
METHOD FOR PROVIDING VASCULAR SYSTEM IN BIOLOGICAL TISSUE
Document Type and Number:
WIPO Patent Application WO/2015/012158
Kind Code:
A1
Abstract:
A method for providing a vascular system in biological tissue in vitro, the method comprising cocultivation of the biological tissue with vascular cells and mesenchymal cells. Biological tissue in which a vascular system has been provided by said method. A method for producing a tissue or organ, the method comprising transplantation of the biological tissue in a non-human animal and inducing differentiation to a tissue or organ in which a vascular network has been constructed. A tissue or organ regeneration or function-restoring method comprising transplantation of the biological tissue in a human or non-human animal and inducing differentiation to a tissue or organ in which a vascular network has been constructed. A method for producing a non-human chimera animal, the method comprising transplantation of the biological tissue to a non-human animal and inducing differentiation to a tissue or organ in which a vascular network has been constructed. A method for evaluating drugs using at least one selected from a group consisting of the biological tissue, tissues and organs produced by said method, and non-human chimera animals produced by said method. A regenerative therapy composition comprising biological tissue in which a vascular system has been provided by said method.
Inventors:
TAKEBE TAKANORI (JP)
TANIGUCHI HIDEKI (JP)
TAKAHASHI YOSHINOBU (JP)
TANIGUCHI HIDEKI (JP)
TAKAHASHI YOSHINOBU (JP)
Application Number:
PCT/JP2014/068808
Publication Date:
January 29, 2015
Filing Date:
July 15, 2014
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY (JP)
International Classes:
C12N5/071; A01K67/027; A61L27/00; C07D499/21; G01N33/50
Domestic Patent References:
| WO2013047639A1 | 2013-04-04 | |||
| WO2008111064A1 | 2008-09-18 | |||
| WO2013047639A1 | 2013-04-04 |
Foreign References:
| JP2013153056A | 2013-08-08 | |||
| JPH0356234A | 1991-03-11 |
Other References:
TAKEBE T. ET AL.: "Vascularized and functional human liver from an iPSC-derived organ bud transplant", NATURE, vol. 499, 3 July 2013 (2013-07-03), pages 481 - 484, XP007922049
KAUFMAN-FRANCIS K. ET AL.: "Engineered Vascular Beds Provide Key Signals to Pancreatic Hormone- Producing Cells", PLOS ONE, vol. 7, no. 7, July 2012 (2012-07-01), pages 1 - 10, XP055139013
TAKAYAMA K ET AL., BIOMATERIALS, vol. 34, no. 7, February 2013 (2013-02-01), pages 1781 - 9
SAITO H ET AL., PLOS ONE., vol. 6, no. 12, 2011, pages E28209
EIRAKU M ET AL., NATURE, vol. 472, 2011, pages 51 - 56
KAUFMAN-FRANCIS K ET AL., PLOS ONE, vol. 7, no. 7, 2012, pages E40741
SAITO H ET AL., PLOS ONE, vol. 6, no. 12, 2011, pages E28209
NATURE, vol. 499, 2013, pages 481 - 484
S. FANG ET AL., PLOS BIOLOGY, vol. 10, no. 10, 2012, pages E1001407
HJ. JOO ET AL., BLOOD, vol. 118, no. 8, 25 December 2010 (2010-12-25), pages 2094 - 104
R. PETERS ET AL., PLOS ONE, vol. 5, no. 12, 30 December 2009 (2009-12-30), pages E15689
"Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis", BLOOD, vol. 118, no. 17, 27 October 2011 (2011-10-27), pages 4740 - 9
KAUFMAN-FRANCIS K. ET AL.: "Engineered Vascular Beds Provide Key Signals to Pancreatic Hormone- Producing Cells", PLOS ONE, vol. 7, no. 7, July 2012 (2012-07-01), pages 1 - 10, XP055139013
TAKAYAMA K ET AL., BIOMATERIALS, vol. 34, no. 7, February 2013 (2013-02-01), pages 1781 - 9
SAITO H ET AL., PLOS ONE., vol. 6, no. 12, 2011, pages E28209
EIRAKU M ET AL., NATURE, vol. 472, 2011, pages 51 - 56
KAUFMAN-FRANCIS K ET AL., PLOS ONE, vol. 7, no. 7, 2012, pages E40741
SAITO H ET AL., PLOS ONE, vol. 6, no. 12, 2011, pages E28209
NATURE, vol. 499, 2013, pages 481 - 484
S. FANG ET AL., PLOS BIOLOGY, vol. 10, no. 10, 2012, pages E1001407
HJ. JOO ET AL., BLOOD, vol. 118, no. 8, 25 December 2010 (2010-12-25), pages 2094 - 104
R. PETERS ET AL., PLOS ONE, vol. 5, no. 12, 30 December 2009 (2009-12-30), pages E15689
"Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis", BLOOD, vol. 118, no. 17, 27 October 2011 (2011-10-27), pages 4740 - 9
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
Setsuko Mayama (JP)
Setsuko Mayama (JP)
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