Title:
METHOD FOR PURIFYING 20(S)-CAMPTOTHECIN
Document Type and Number:
WIPO Patent Application WO2002064597
Kind Code:
A3
Abstract:
The invention relates to a method for purifying 20(S) camptothecin by transforming the lactone ring of the 20(S) camptothecin into a carboxylate salt with the help of an aqueous base, hydrogenating the mixture that is obtained in the presence of a transition metal catalyst, acidifying the aqueous phase to form camptothecin crystals, adding a polar aprotic solvent, optionally heating and cooling the mixture and separating the camptothecin crystals.
Inventors:
SOBOTTA RAINER (DE)
RAPP ARMIN (DE)
RAPP ARMIN (DE)
Application Number:
PCT/EP2002/001375
Publication Date:
October 24, 2002
Filing Date:
February 09, 2002
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA (DE)
SOBOTTA RAINER (DE)
RAPP ARMIN (DE)
SOBOTTA RAINER (DE)
RAPP ARMIN (DE)
International Classes:
B01D9/02; C07D491/04; C07D491/14; C07D491/22; (IPC1-7): C07D491/04
Domestic Patent References:
| WO1994019353A1 | 1994-09-01 |
Other References:
IAYAMA R ET AL: "A CAMPTOTHECIN DERIVATIVE FROM NOTHAPODYTES FOETIDA", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 11, no. 27, 1988, pages 3663 - 3664, XP008006380, ISSN: 0031-9422
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