Title:
METHOD FOR PURIFYING HIGH-PURITY BETULONIC ACID, METHOD FOR PREPARING PIPERAZINE BETULONIC ACID AMIDE DERIVATIVE USING HIGH-PURITY BETULONIC ACID AND DERIVATIVE THEREOF, AND METHOD FOR PURIFYING HIGH-PURITY BOC-LYSINATED BETULONIC ACID USING HIGH-PURITY BETULONIC ACID
Document Type and Number:
WIPO Patent Application WO/2013/002592
Kind Code:
A2
Abstract:
The present invention relates to a method for purifying high-purity betulonic acid, a method for preparing a piperazine betulonic acid amide derivative using high-purity betulonic acid and a derivative thereof, and a method for purifying high-purity Boc-lysinated betulonic acid using high-purity betulonic acid. The present invention relates to a method for purifying high-purity betulonic acid from a product of an organic synthetic reaction between betulin extracted from the bark of a birch and a Jones oxidation reagent, synthesis of piperazine betulonic acid amide derivative using the same, utilization thereof as an antibacterial drug, purification of high-purity Boc-lysinated betulonic acid monomer ester from a product of an organic synthetic reaction between high-purity betulonic acid and lysine, and purification of high-purity Boc-lysinated betulonic acid from a product of hydrolysis of the Boc-lysinated betulonic acid monomer ester.
Inventors:
CHUE KUCK-TACK (KR)
KIM TAE-HWAN (KR)
TEN LEONID (KR)
KIM TAE-HWAN (KR)
TEN LEONID (KR)
Application Number:
PCT/KR2012/005154
Publication Date:
January 03, 2013
Filing Date:
June 29, 2012
Export Citation:
Assignee:
KOREA ENERGY RESEARCH INST (KR)
CHUE KUCK-TACK (KR)
KIM TAE-HWAN (KR)
TEN LEONID (KR)
CHUE KUCK-TACK (KR)
KIM TAE-HWAN (KR)
TEN LEONID (KR)
Foreign References:
| US20100190795A1 | 2010-07-29 | |||
| KR100351704B1 | 2002-08-23 | |||
| KR100376282B1 | 2003-03-04 | |||
| KR100902846B1 | 2009-06-16 |
Other References:
YOGEESWARI, P. ET AL.: 'Betulinic Acid and Its Derivatives: A Review on their Biological Properties' CURRENT MEDICINAL CHEMISTRY vol. 12, 2005, pages 657 - 666
LEONID, T. ET AL.: 'Extraction, crystallization, and continuous chromatographic processing for ultra pure betulin and high pure betulinic acid from birch barks' THEORIES AND APPLICATIONS OF CHEMICAL ENGINEERING vol. 16, 2010, page 1572
ANTIMONOVA, A. N. ET AL.: 'SYNTHESIS OF BETULONIC ACID AMIDES' CHEMISTRY OF NATURAL COMPOUNDS vol. 44, 2008, pages 327 - 333
LEONID, T. ET AL.: 'Extraction, crystallization, and continuous chromatographic processing for ultra pure betulin and high pure betulinic acid from birch barks' THEORIES AND APPLICATIONS OF CHEMICAL ENGINEERING vol. 16, 2010, page 1572
ANTIMONOVA, A. N. ET AL.: 'SYNTHESIS OF BETULONIC ACID AMIDES' CHEMISTRY OF NATURAL COMPOUNDS vol. 44, 2008, pages 327 - 333
Attorney, Agent or Firm:
CHANG, Soon-Boo et al. (KR)
장순부 (KR)
장순부 (KR)
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Claims: