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Title:
METHOD FOR PURIFYING HIGH-PURITY BETULONIC ACID, METHOD FOR PREPARING PIPERAZINE BETULONIC ACID AMIDE DERIVATIVE USING HIGH-PURITY BETULONIC ACID AND DERIVATIVE THEREOF, AND METHOD FOR PURIFYING HIGH-PURITY BOC-LYSINATED BETULONIC ACID USING HIGH-PURITY BETULONIC ACID
Document Type and Number:
WIPO Patent Application WO/2013/002592
Kind Code:
A3
Abstract:
The present invention relates to a method for purifying high-purity betulonic acid, a method for preparing a piperazine betulonic acid amide derivative using high-purity betulonic acid and a derivative thereof, and a method for purifying high-purity Boc-lysinated betulonic acid using high-purity betulonic acid. The present invention relates to a method for purifying high-purity betulonic acid from a product of an organic synthetic reaction between betulin extracted from the bark of a birch and a Jones oxidation reagent, synthesis of piperazine betulonic acid amide derivative using the same, utilization thereof as an antibacterial drug, purification of high-purity Boc-lysinated betulonic acid monomer ester from a product of an organic synthetic reaction between high-purity betulonic acid and lysine, and purification of high-purity Boc-lysinated betulonic acid from a product of hydrolysis of the Boc-lysinated betulonic acid monomer ester.

Inventors:
CHUE, Kuck-Tack (4 Expo APT, Jeonmin-Dong Yuseong-Gu, Daejeon 305-762, 305-762, KR)
주국택 (305-762 대전광역시 유성구 전민동 엑스포아파트, Daejeon, 305-762, KR)
KIM, Tae-Hwan (207-203, Expo APT.Jeonmin-Dong, Yuseong-Gu, Daejeon 305-761, 305-761, KR)
Application Number:
KR2012/005154
Publication Date:
January 03, 2013
Filing Date:
June 29, 2012
Export Citation:
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Assignee:
KOREA INSTITUTE OF ENERGY RESEARCH (71-2, Jang-Dong Yuseong-Gu, Daejeon 305-343, 305-343, KR)
한국에너지기술연구원 (305-343 대전광역시 유성구 장동 71-2, Daejeon, 305-343, KR)
CHUE, Kuck-Tack (4 Expo APT, Jeonmin-Dong Yuseong-Gu, Daejeon 305-762, 305-762, KR)
주국택 (305-762 대전광역시 유성구 전민동 엑스포아파트, Daejeon, 305-762, KR)
International Classes:
C07J3/00; C07D295/033; C07D401/04; C07J5/00
Foreign References:
US20100190795A12010-07-29
KR100351704B12002-08-23
KR100376282B12003-03-04
KR100902846B12009-06-16
Other References:
YOGEESWARI, P. ET AL.: 'Betulinic Acid and Its Derivatives: A Review on their Biological Properties' CURRENT MEDICINAL CHEMISTRY vol. 12, 2005, pages 657 - 666
LEONID, T. ET AL.: 'Extraction, crystallization, and continuous chromatographic processing for ultra pure betulin and high pure betulinic acid from birch barks' THEORIES AND APPLICATIONS OF CHEMICAL ENGINEERING vol. 16, 2010, page 1572
ANTIMONOVA, A. N. ET AL.: 'SYNTHESIS OF BETULONIC ACID AMIDES' CHEMISTRY OF NATURAL COMPOUNDS vol. 44, 2008, pages 327 - 333
Attorney, Agent or Firm:
CHANG, Soon-Boo et al. (B-812 Woolim Lion's Valley, 371-28 Gasan-dong, Geumcheon-gu, Seoul 153-803, 153-803, KR)
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Claims: