METHOD FOR PURIFYING AND ISOLATING (2S,3S)- OR (2R,3S)-HALOHYDRIN DERIVATIVES

Title:

METHOD FOR PURIFYING AND ISOLATING (2S,3S)- OR (2R,3S)-HALOHYDRIN DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2000/043357

Kind Code:

A1

Abstract:

To efficiently isolate (2S,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutanes (1) or (2R,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutanes (2) with excellent qualities, impurities are eliminated from a mixture containing the above compounds (1) and/or the above compounds (2) by crystallizing the target compounds (1) or (2) in the presence of a solvent comprising a hydrocarbon solvent and then collecting the crystals.

Inventors:

MAEHARA KATSUJI (JP)
KAWANO SHIGERU (JP)
YAMAGUCHI MAKOTO (JP)
UEDA YASUYOSHI (JP)

Application Number:

PCT/JP2000/000275

Publication Date:

July 27, 2000

Filing Date:

January 21, 2000

Export Citation:

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Assignee:

KANEKA CORP (JP)
MAEHARA KATSUJI (JP)
KAWANO SHIGERU (JP)
YAMAGUCHI MAKOTO (JP)
UEDA YASUYOSHI (JP)

International Classes:

C07C269/08; C12P13/02; C12P41/00; C07C271/16; (IPC1-7): C07C269/08; C07C271/16; C12P13/02

Foreign References:

US5481011A	1996-01-02
US5726047A	1998-03-10

Other References: