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Title:
METHOD FOR PURIFYING P1,P4-DI(URIDINE 5'-)TETRAPHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2018/079503
Kind Code:
A1
Abstract:
Provided is a simple and practical method for removing iron ions, as a method for purifying P1,P4-di(uridine 5'-)tetraphosphate from a solution that contains iron ions. This method for purifying P1,P4-di(uridine 5'-)tetraphosphate by removing iron ions from an aqueous solution or hydrophilic solvent solution containing P1,P4-di(uridine 5'-)tetraphosphate and iron ions includes: (1) a column purification step that uses a chelate resin, and (2) a step for adjusting the pH of the solution to 5.5 or less following the chelate resin column purification, and then crystallizing P1,P4-di(uridine 5'-)tetraphosphate; or a step for treating the solution with zinc chloride-activated activated carbon following the chelate resin column purification.

Inventors:
OHBA YUSUKE (JP)
OYAMA TOMOKO (JP)
KANO FUMITAKA (JP)
UCHINO ASUKA (JP)
Application Number:
JP2017/038237
Publication Date:
May 03, 2018
Filing Date:
October 24, 2017
Export Citation:
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Assignee:
YAMASA CORP (JP)
International Classes:
C07H19/10; A61K31/7105; A61P27/02
Domestic Patent References:
WO2014103704A12014-07-03
WO2008012949A12008-01-31
WO2008012949A12008-01-31
WO2008024169A12008-02-28
WO2014103704A12014-07-03
WO2000020430A12000-04-13
Foreign References:
Other References:
YANACHKOV, IVAN B. ET AL: "P 1 ,P2-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates – synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs", ORG BIOMOL CHEM, vol. 9, no. 3, 2011, pages 730 - 738, XP009514869, DOI: 10.1039/cOob00542h
NISHINO, HIROSHI: "Active carbon C", SSOC JOURNAL, vol. 40, no. 9, 1982, pages 853 - 854, XP055598776, DOI: 10.5059/yukigoseikyokaishi.40.853
AOKI, HIROYUKI ET AL.: "Industrial production and market of activated carbon", TANSO, vol. 232, 1 January 2008 (2008-01-01), pages 98 - 107, XP055598790, DOI: 10.7209/tanso.2008.98
See also references of EP 3546472A4
BIOORG. & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 157 - 160
ORG. BIOMOL. CHEM., 2011, pages 730 - 738
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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