Title:
METHOD FOR QUANTIFYING BRAIN INJURIES
Document Type and Number:
WIPO Patent Application WO/2014/060695
Kind Code:
A3
Abstract:
The invention relates to an ex vivo method for detecting and/or quantifying brain injuries. The invention also relates to an ex vivo method for monitoring the evolution of a brain injury, and to an ex vivo method for predicting when a patient will come out of a coma. For the evaluation of brain injuries, fractional anisotropy, axial diffusivity and radial diffusivity values obtained by magnetic resonance imaging are used. These measurements are also used to predict when a patient will come out of a coma, for which purpose an algorithm predetermined by a classification software program is used. The invention is particularly applicable in the field of medicine and in the field of clinical studies.
Inventors:
PUYBASSET LOUIS (FR)
GALANAUD DAMIEN (FR)
BENALI HABIB (FR)
PERLBARG VINCENT (FR)
LEHERICY STÉPHANE (FR)
GALANAUD DAMIEN (FR)
BENALI HABIB (FR)
PERLBARG VINCENT (FR)
LEHERICY STÉPHANE (FR)
Application Number:
PCT/FR2013/052454
Publication Date:
June 26, 2014
Filing Date:
October 15, 2013
Export Citation:
Assignee:
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS (FR)
International Classes:
A61B5/055; A61B5/00; G01R33/563; G06T7/00
Other References:
KAREN CAEYENBERGHS ET AL: "Brain-behavior relationships in young traumatic brain injury patients: DTI metrics are highly correlated with postural control", HUMAN BRAIN MAPPING, vol. 31, no. 7, 8 July 2010 (2010-07-08), pages 992 - 1002, XP055069954, ISSN: 1065-9471, DOI: 10.1002/hbm.20911
S. WANG ET AL: "Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of White Matter Using Diffusion Tensor MR Imaging", AJNR, AMERICAN JOURNAL OF NEURORADIOLOGY, vol. 30, no. 10, 1 November 2009 (2009-11-01), pages 1907 - 1913, XP055069764, ISSN: 0195-6108, DOI: 10.3174/ajnr.A1697
METWALLI N S ET AL: "Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral sclerosis", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1348, 12 August 2010 (2010-08-12), pages 156 - 164, XP027174295, ISSN: 0006-8993, [retrieved on 20100601]
CHAN K C ET AL: "Late measures of microstructural alterations in severe neonatal hypoxic-ischemic encephalopathy by MR diffusion tensor imaging", INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, PERGAMON, OXFORD, GB, vol. 27, no. 6, 1 October 2009 (2009-10-01), pages 607 - 615, XP026469807, ISSN: 0736-5748, [retrieved on 20090606], DOI: 10.1016/J.IJDEVNEU.2009.05.012
MIIA PITKONEN ET AL: "Long-term evolution of diffusion tensor indices after temporary experimental ischemic stroke in rats", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1445, 19 January 2012 (2012-01-19), pages 103 - 110, XP028467880, ISSN: 0006-8993, [retrieved on 20120128], DOI: 10.1016/J.BRAINRES.2012.01.043
VINCENT PERLBARG ET AL: "Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: A diffusion tensor imaging study using voxel-based approaches", HUMAN BRAIN MAPPING, vol. 30, no. 12, 8 June 2009 (2009-06-08), pages 3924 - 3933, XP055033741, ISSN: 1065-9471, DOI: 10.1002/hbm.20817
JOSHUA BETZ ET AL: "Prognostic Value of Diffusion Tensor Imaging Parameters in Severe Traumatic Brain Injury", JOURNAL OF NEUROTRAUMA, vol. 29, no. 7, 17 April 2012 (2012-04-17), pages 1292 - 1305, XP055076969, ISSN: 0897-7151, DOI: 10.1089/neu.2011.2215
ONI MARGARET B ET AL: "Diffusion Tensor Imaging Analysis of Frontal Lobes in Pediatric Traumatic Brain Injury", JOURNAL OF CHILD NEUROLOGY, DECKER PERIODICALS, HAMILTON, CA, vol. 25, no. 8, 1 August 2010 (2010-08-01), pages 976 - 984, XP008168487, ISSN: 0883-0738, [retrieved on 20100323], DOI: 10.1177/0883073809356034
S. WANG ET AL: "Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of White Matter Using Diffusion Tensor MR Imaging", AJNR, AMERICAN JOURNAL OF NEURORADIOLOGY, vol. 30, no. 10, 1 November 2009 (2009-11-01), pages 1907 - 1913, XP055069764, ISSN: 0195-6108, DOI: 10.3174/ajnr.A1697
METWALLI N S ET AL: "Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral sclerosis", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1348, 12 August 2010 (2010-08-12), pages 156 - 164, XP027174295, ISSN: 0006-8993, [retrieved on 20100601]
CHAN K C ET AL: "Late measures of microstructural alterations in severe neonatal hypoxic-ischemic encephalopathy by MR diffusion tensor imaging", INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, PERGAMON, OXFORD, GB, vol. 27, no. 6, 1 October 2009 (2009-10-01), pages 607 - 615, XP026469807, ISSN: 0736-5748, [retrieved on 20090606], DOI: 10.1016/J.IJDEVNEU.2009.05.012
MIIA PITKONEN ET AL: "Long-term evolution of diffusion tensor indices after temporary experimental ischemic stroke in rats", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1445, 19 January 2012 (2012-01-19), pages 103 - 110, XP028467880, ISSN: 0006-8993, [retrieved on 20120128], DOI: 10.1016/J.BRAINRES.2012.01.043
VINCENT PERLBARG ET AL: "Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: A diffusion tensor imaging study using voxel-based approaches", HUMAN BRAIN MAPPING, vol. 30, no. 12, 8 June 2009 (2009-06-08), pages 3924 - 3933, XP055033741, ISSN: 1065-9471, DOI: 10.1002/hbm.20817
JOSHUA BETZ ET AL: "Prognostic Value of Diffusion Tensor Imaging Parameters in Severe Traumatic Brain Injury", JOURNAL OF NEUROTRAUMA, vol. 29, no. 7, 17 April 2012 (2012-04-17), pages 1292 - 1305, XP055076969, ISSN: 0897-7151, DOI: 10.1089/neu.2011.2215
ONI MARGARET B ET AL: "Diffusion Tensor Imaging Analysis of Frontal Lobes in Pediatric Traumatic Brain Injury", JOURNAL OF CHILD NEUROLOGY, DECKER PERIODICALS, HAMILTON, CA, vol. 25, no. 8, 1 August 2010 (2010-08-01), pages 976 - 984, XP008168487, ISSN: 0883-0738, [retrieved on 20100323], DOI: 10.1177/0883073809356034
Attorney, Agent or Firm:
NOVAGRAAF TECHNOLOGIES (Levallois-Perret Cedex, FR)
Download PDF:
Previous Patent: CONTAINER FOR A LIQUID, COMPRISING A POUCH
Next Patent: METHOD AND FACILITY FOR TREATING CORK
Next Patent: METHOD AND FACILITY FOR TREATING CORK