METHOD FOR QUANTITATING DENATURED LDLS

Title:

METHOD FOR QUANTITATING DENATURED LDLS

Document Type and Number:

WIPO Patent Application WO/1999/032520

Kind Code:

A1

Abstract:

An assay method commonly usable in the clinical field whereby denatured LDLs such as oxidized LDL contained in the body fluids of patients with arteriosclerosis, hyperlipemia, etc. can be conveniently detected and quantitated in an intact state at a high sensitivity; and a fused polypeptide to be used as a constituent in the above assay method, which is composed of the extracellular region of a mammalian oxidized LDL receptor and a part of the heavy chain of a mammalian immunoglobulin. This fused polypeptide per se is useful as the active ingredient in drugs for preventing and treating arteriosclerosis, hyperlipemia, etc.

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Inventors:

SAWAMURA TATSUYA (JP)
KAKUTANI MAKOTO (JP)
MASAKI TOMOH (JP)

Application Number:

PCT/JP1998/005744

Publication Date:

July 01, 1999

Filing Date:

December 18, 1998

Export Citation:

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Assignee:

JAPAN TOBACCO INC (JP)
SAWAMURA TATSUYA (JP)
KAKUTANI MAKOTO (JP)
MASAKI TOMOH (JP)

International Classes:

C12N15/09; A61K31/00; A61K38/00; A61K39/395; A61P3/00; A61P3/06; A61P9/00; A61P9/10; C07K1/22; C07K14/705; C07K16/46; C07K17/00; C07K19/00; C12N5/10; C12N15/00; C12P21/02; G01N33/53; G01N33/92; C12R1/91; (IPC1-7): C07K19/00; A61K38/17; C07K14/705; C07K17/00; C12N15/62; G01N33/53

Foreign References:

JPH0998787A	1997-04-15
JPH06160395A	1994-06-07
JPH05247094A	1993-09-24

Other References: