Title:
METHOD AND REAGENT FOR DETECTING BACTERIUM INVOLVED WITH DEVELOPMENT OF RHEUMATOID ARTHRITIS, AND METHOD AND AGENT FOR DETERMINING PRESENCE OR ABSENCE OF PREDISPOSITION TO RHEUMATOID ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2021/100875
Kind Code:
A1
Abstract:
The objective of the present invention is to provide a means for identifying a bacterium associated with the development of rheumatoid arthritis and determining the possibility of contracting rheumatoid arthritis earlier and more easily using the bacterium. The present invention relates to a method and reagent for detecting a bacterium involved with the development of rheumatoid arthritis, and a method and agent for determining the presence or absence of a predisposition to rheumatoid arthritis.
Inventors:
TAKEDA KIYOSHI (JP)
MAEDA YUICHI (JP)
KOIZUMI SATOSHI (JP)
YAMASHITA MAKOTO (JP)
YAMAZAKI FUHITO (JP)
HAYASHI MIKIRO (JP)
MAEDA YUICHI (JP)
KOIZUMI SATOSHI (JP)
YAMASHITA MAKOTO (JP)
YAMAZAKI FUHITO (JP)
HAYASHI MIKIRO (JP)
Application Number:
PCT/JP2020/043510
Publication Date:
May 27, 2021
Filing Date:
November 20, 2020
Export Citation:
Assignee:
UNIV OSAKA (JP)
KYOWA HAKKO BIO CO LTD (JP)
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
C12Q1/6813; C12Q1/686; C12Q1/689; G01N33/53; G01N33/569; C12N15/09
Domestic Patent References:
| WO2016119191A1 | 2016-08-04 | |||
| WO2013056222A1 | 2013-04-18 | |||
| WO2017214180A1 | 2017-12-14 |
Foreign References:
| US20160186261A1 | 2016-06-30 |
Other References:
SCHER, J. U. ET AL.: "Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis", ELIFE, vol. 2, 2013, pages 1 - 20, XP055475267, DOI: 10.7554/eLife.01202
LORENZO, D. ET AL.: "Oral-Gut Microbiota and Arthritis: Is There an Evidence - Based Axis?", J. CLIN. MED., vol. 8, no. 10, 22 October 2019 (2019-10-22), pages 1753, XP055825741
PIANTA, A. ET AL.: "Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis", ARTHRITIS RHEUMATOL., vol. 69, no. 5, 2017, pages 964 - 975, XP055658377, DOI: 10.1002/art.40003
TAKEDA, KIYOSHI ET AL.: "Intestinal Flora and Rheumatism", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 40, no. 4, 2017, pages 256
MAEDA, YUICHI ET AL.: "Intestinal microbiota in health and disease", EXPERIMENTAL MEDICINE, vol. 37, no. 7, 1 May 2019 (2019-05-01), pages 103 - 107
MAEDA, Y. ET AL.: "Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine", ARTHRITIS RHEUMATOL., vol. 68, no. 11, 2016, pages 2646 - 2661, XP055337706, DOI: 10.1002/art.39783
MAEDA, Y. ET AL.: "Altered composition of gut microbiota in rheumatoid arthritis patients", JPN. J. CLIN. IMMUNOL., vol. 39, no. 1, 2016, pages 59 - 63, XP055825744
NII, TAKURO ET AL.: "The Immune Response to Prevotella Bacteria in Autoimmune Diseases", JAPANESE JOURNAL OF ALLERGOLOGY., vol. 67, no. 1, 2018, pages 24 - 27
KISHIKAWA, T. ET AL.: "Metagenome-wide associationstudy of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population", ANN. RHEUM. DIS., vol. 79, no. 1, 7 November 2019 (2019-11-07), pages 103 - 111, XP055797612
METWALY, A. ET AL.: "Strain-Level Diversity in the Gut: The P. copri Case", CELL HOST MICROBE, vol. 25, no. 3, 13 March 2019 (2019-03-13), pages 349 - 350, XP085630062
MANICHANH, C. ET AL.: "A comparison of random sequence reads versus 16S rDNA sequences for estimating the biodiversity of a metagenomic library", NUCLEIC ACIDS RES., vol. 36, no. 16, 2008, pages 5180 - 5188, XP055049105, DOI: 10.1093/nar/gkn496
LORENZO, D. ET AL.: "Oral-Gut Microbiota and Arthritis: Is There an Evidence - Based Axis?", J. CLIN. MED., vol. 8, no. 10, 22 October 2019 (2019-10-22), pages 1753, XP055825741
PIANTA, A. ET AL.: "Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis", ARTHRITIS RHEUMATOL., vol. 69, no. 5, 2017, pages 964 - 975, XP055658377, DOI: 10.1002/art.40003
TAKEDA, KIYOSHI ET AL.: "Intestinal Flora and Rheumatism", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 40, no. 4, 2017, pages 256
MAEDA, YUICHI ET AL.: "Intestinal microbiota in health and disease", EXPERIMENTAL MEDICINE, vol. 37, no. 7, 1 May 2019 (2019-05-01), pages 103 - 107
MAEDA, Y. ET AL.: "Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine", ARTHRITIS RHEUMATOL., vol. 68, no. 11, 2016, pages 2646 - 2661, XP055337706, DOI: 10.1002/art.39783
MAEDA, Y. ET AL.: "Altered composition of gut microbiota in rheumatoid arthritis patients", JPN. J. CLIN. IMMUNOL., vol. 39, no. 1, 2016, pages 59 - 63, XP055825744
NII, TAKURO ET AL.: "The Immune Response to Prevotella Bacteria in Autoimmune Diseases", JAPANESE JOURNAL OF ALLERGOLOGY., vol. 67, no. 1, 2018, pages 24 - 27
KISHIKAWA, T. ET AL.: "Metagenome-wide associationstudy of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population", ANN. RHEUM. DIS., vol. 79, no. 1, 7 November 2019 (2019-11-07), pages 103 - 111, XP055797612
METWALY, A. ET AL.: "Strain-Level Diversity in the Gut: The P. copri Case", CELL HOST MICROBE, vol. 25, no. 3, 13 March 2019 (2019-03-13), pages 349 - 350, XP085630062
MANICHANH, C. ET AL.: "A comparison of random sequence reads versus 16S rDNA sequences for estimating the biodiversity of a metagenomic library", NUCLEIC ACIDS RES., vol. 36, no. 16, 2008, pages 5180 - 5188, XP055049105, DOI: 10.1093/nar/gkn496
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (JP)
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