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Title:
METHOD AND REAGENT KIT FOR MEASURING CHOLESTEROL UPTAKE CAPACITY OF LIPOPROTEINS
Document Type and Number:
WIPO Patent Application WO/2016/194825
Kind Code:
A1
Abstract:
The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. Furthermore, the present invention relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. Further, the present invention relates to a tagged cholesterol, which can be used in the method and the reagent kit.

Inventors:
YOSHIKAWA, Keiko (5-1 Wakinohama-kaigandori 1-chome, Chuo-ku, Kobe-sh, Hyogo 73, 〒6510073, JP)
HARADA, Amane (5-1 Wakinohama-kaigandori 1-chome, Chuo-ku, Kobe-sh, Hyogo 73, 〒6510073, JP)
MURAKAMI, Katsuhiro (5-1 Wakinohama-kaigandori 1-chome, Chuo-ku, Kobe-sh, Hyogo 73, 〒6510073, JP)
KIRIYAMA, Maria (5-1 Wakinohama-kaigandori 1-chome, Chuo-ku, Kobe-sh, Hyogo 73, 〒6510073, JP)
MIWA, Keiko (5-1 Wakinohama-kaigandori 1-chome, Chuo-ku, Kobe-sh, Hyogo 73, 〒6510073, JP)
KUBO, Takuya (5-1 Wakinohama-kaigandori 1-chome, Chuo-ku, Kobe-sh, Hyogo 73, 〒6510073, JP)
Application Number:
JP2016/065753
Publication Date:
December 08, 2016
Filing Date:
May 27, 2016
Export Citation:
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Assignee:
SYSMEX CORPORATION (5-1 Wakinohama-kaigandori 1-chome, Chuo-ku Kobe-sh, Hyogo 73, 〒6510073, JP)
International Classes:
G01N33/53; G01N33/543; G01N33/58; G01N33/92
Domestic Patent References:
WO2012104411A12012-08-09
WO2006028241A12006-03-16
Foreign References:
JP2011184374A2011-09-22
JP2015020969A2015-02-02
JP2008139299A2008-06-19
JP2004354284A2004-12-16
EP1114870A12001-07-11
JP2007515632A2007-06-14
JP2008542688A2008-11-27
JP4610337B22011-01-12
JP2016080685A2016-05-16
Other References:
"Kakushu Keiko Hyoshiki Cholesterol | Hyoshikitai | Cholesterol Oyobi Yudotai | Funakoshi", 2010, Retrieved from the Internet [retrieved on 20160802]
GAIBELET GERALD: "21-Methylpyrenyl-cholesterol stably and specifically associates with lipoprotein peripheral hemi-membrane: A new labelling tool", BIOCHEM BIOPHYS RES COMMUN, vol. 440, no. 4, 2013, pages 533 - 538, XP028761551
HEUCK C C: "Cholesterol determination in serum after fractionation of lipoproteins by immunoprecipitation", CLINICAL CHEMISTRY, vol. 31, no. 2, 1985, pages 252 - 256, XP055241391
SHIZUYA YAMASHITA: "Risk to shite no Koshikessho Tokushu na Koshikessho CETP Kessonsho", GEKKAN RINSHO TO KENKYU, vol. 78, no. 5, 2001, pages 844 - 849, XP009500132
SHUNNOSUKE HANDA: "9) Research on origins of coronary sclerosis -Relation between CETP and HTGL", RINSHO SEIJINBYO, vol. 27, no. 10, 1997, pages 1366 - 1367, XP009500130
JONAS A: "Incorporation of excess cholesterol by high density serum lipoproteins", BIOCHIM BIOPHYS ACTA, vol. 528, no. 1, 1978, pages 47 - 57, XP055241391
LUNDBERG B: "Incorporation of cholesterol into serum high and low density lipoproteins", CHEM PHYS LIPIDS, vol. 31, no. 3, 1982, pages 275 - 282, XP024553267
CESAR THAIS B.: "Orange juice decreases low- density lipoprotein cholesterol in hypercholesterolemic subjects and improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemic subjects", NUTR RES, vol. 30, no. 10, 2010, pages 689 - 694, XP027554769
STAPRANS ILONA: "Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins", J LIPID RES, vol. 47, no. 11, 2006, pages 2575 - 2580, XP055332848
See also references of EP 3225993A4
Attorney, Agent or Firm:
NOGAWA, Shintaro et al. (Nogawa Patent Office, Nishitenma Five Bldg. 16-3, Nishitenma 5-chome, Kita-ku, Osaka-sh, Osaka 47, 〒5300047, JP)
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