METHOD FOR REDUCING PLURIPOTENT STEM CELLS, METHOD FOR PRODUCING CELL POPULATION HAVING REDUCED PLURIPOTENT STEM CELLS

WIPO Patent Application WO/2017/038562

A1

The present invention pertains to a method for culturing a cell population including pluripotent stem cells and differentiated cells derived from pluripotent stem cells at a temperature of 40.5°C or higher and reducing the pluripotent stem cells included in the cell population. The present invention also pertains to a method for reducing pluripotent stem cells from a cell population including pluripotent stem cells and differentiated cells derived from pluripotent stem cells, wherein the method includes a step for activating the TRPV-1 expressed in the pluripotent stem cells included in the cell population. The presesnt invention makes it possible to reduce the pluripotent stem cells remaining in an undifferentiated state when inducing the differentiation of a pluripotent stem cell population.

MATSUURA KATSUHISA (JP)
SHIMIZU TATSUYA (JP)
SETA HIROYOSHI (JP)

PCT/JP2016/074545

March 09, 2017

August 23, 2016

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TOKYO WOMEN'S MEDICAL UNIV (JP)

C12N5/10; C12N5/0735; C12N15/09

WO2012133945A1	2012-10-04
WO2013137491A1	2013-09-19

QI YAN ET AL.: "Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes", PLOS ONE, vol. 10, no. 7, 24 July 2015 (2015-07-24), pages e0133211, XP055367697
MATSUURA KATSUHISA: "TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues", SCIENTIFIC REPORTS, vol. 6, 18 February 2016 (2016-02-18), pages 21747, XP055367698
See also references of EP 3346002A4

AOKI, Atsushi et al. (JP)

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