Title:
METHOD OF REGENERATING DENTIN
Document Type and Number:
WIPO Patent Application WO/2005/079728
Kind Code:
A1
Abstract:
It is intended to provide an economical and safe method of regenerating dentin and a material therefor. Namely, a method of regenerating dentin characterized by comprising culturing pulp cells with the use of a complex material containing non-collagenous phosphorylated protein and collagen as a scaffold; and a material for repairing dentin which is prepared by crosslinking a non-collagenous phosphorylated protein with collagen by using divinylsulfone or 1-ethyl-3-(3-dimethylaminoprooyl)carbodiamide followed by freeze-drying or gelling by heating.
Inventors:
UEMURA TOSHIMASA (JP)
SAITO TAKASHI (JP)
FUJII TAKEO (JP)
SAITO TAKASHI (JP)
FUJII TAKEO (JP)
Application Number:
PCT/JP2005/003408
Publication Date:
September 01, 2005
Filing Date:
February 23, 2005
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
UEMURA TOSHIMASA (JP)
SAITO TAKASHI (JP)
FUJII TAKEO (JP)
UEMURA TOSHIMASA (JP)
SAITO TAKASHI (JP)
FUJII TAKEO (JP)
International Classes:
A61C5/00; A61C13/08; A61K6/00; A61K6/838; A61K6/884; A61K6/891; A61K35/32; A61L27/00; A61L27/24; A61L27/26; A61L27/36; C12N5/077; (IPC1-7): A61K6/08; A61C5/00; A61C13/08; A61K6/033; A61K6/087; A61K35/32; A61L27/00; C12N5/06
Foreign References:
| JP2003070290A | 2003-03-07 | |||
| JPS62224357A | 1987-10-02 |
Other References:
SAITO T. ET AL: "Zogeshitsu Saisakkaika to Shizui Saibo kara Zoge Gasaibo heno Bunka.", QUITESSENCE., vol. 22, no. 1, 2003, pages 216 - 219, XP002904431
SAITO T. ET AL: "Zogeshitsu Kishitsu Model to shiteno Phosphophorin-Sai Kosei Kollagen Sen'I Fukugotai no yoru Sekkai Yudo (Apatite induction by phosphophoryn-reconstituted collagen fibrils complex as a model dentin collagen)", NIHON SHIKA HOZONGAKU ZASSHI., vol. 42, no. 4, 1999, pages 776 - 782, XP002997253
SAITO T. ET AL: "Phosphoprotein-Saikosei Kollagen Sen'I Fukugotai no yoru Sekkaika Yudo Kollagen Sen'I Kozo ga Sekkaika ni Oyobosu Eikyo (Mineral induction by phosphoprotein-reconstituted collagen fibrils complex)", NIHON SHIKA HOZONGAKU ZASSHI., vol. 43, no. 4, 2000, pages 826 - 831, XP002997254
SAITO T. ET AL: "Zogeshitsu Kishitsu Model to shiteno Phosphophorin-Sai Kosei Kollagen Sen'I Fukugotai no yoru Sekkai Yudo (Apatite induction by phosphophoryn-reconstituted collagen fibrils complex as a model dentin collagen)", NIHON SHIKA HOZONGAKU ZASSHI., vol. 42, no. 4, 1999, pages 776 - 782, XP002997253
SAITO T. ET AL: "Phosphoprotein-Saikosei Kollagen Sen'I Fukugotai no yoru Sekkaika Yudo Kollagen Sen'I Kozo ga Sekkaika ni Oyobosu Eikyo (Mineral induction by phosphoprotein-reconstituted collagen fibrils complex)", NIHON SHIKA HOZONGAKU ZASSHI., vol. 43, no. 4, 2000, pages 826 - 831, XP002997254
Attorney, Agent or Firm:
Hiraki, Yusuke (3-20 Toranomon 4-chome, Minato-k, Tokyo 01, JP)
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