Title:
METHOD FOR REPAIRING A MUTANT RNA FROM A DNA WITH GENETIC DEFECTS AND FOR THE PROGRAMMED DEATH OF TUMOUR CELLS BY RNA TRANS-SPLICING AS WELL AS A METHOD FOR IDENTIFYING NATURALLY TRANS-SPLICED CELLULAR RNA
Document Type and Number:
WIPO Patent Application WO2003016537
Kind Code:
A3
Abstract:
The invention relates to methods and products for repairing DNA with genetic defects in the area of a mutant exon, for the programmed death of tumour cells as well as for identifying naturally trans-spliced RNA, whereby said methods are based on the use of RNA spliced components, produced naturally in the cell.
Inventors:
EUL JOACHIM (DE)
Application Number:
PCT/EP2002/009082
Publication Date:
January 29, 2004
Filing Date:
August 13, 2002
Export Citation:
Assignee:
AESCU LIFE GMBH (DE)
EUL JOACHIM (DE)
EUL JOACHIM (DE)
International Classes:
C12N5/22; C12N15/10; (IPC1-7): C12N15/63; C12Q1/68
Domestic Patent References:
| WO2002053581A2 | 2002-07-11 |
Other References:
CAUDEVILLA CONCHA ET AL: "Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing.", NUCLEIC ACIDS RESEARCH, vol. 29, no. 14, 15 July 2001 (2001-07-15), pages 3108 - 3115, XP002251616, ISSN: 0305-1048
CONRAD R ET AL: "INSERTION OF PART OF AN INTRON INTO THE 5' UNTRANSLATED REGION OF A CAENORHABDITIS ELEGANS GENE CONVERTS ITS INTO A TRANS-SPLICED GENE", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 11, no. 4, April 1991 (1991-04-01), pages 1921 - 1926, XP001073410, ISSN: 0270-7306
EUL JOACHIM ET AL: "Experimental evidence for RNA trans-splicing in mammalian cells.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 14, no. 13, 1995, pages 3226 - 3235, XP001154331, ISSN: 0261-4189
EUL J ET AL: "Trans-splicing and alternative-tandem-cis-splicing: Two ways by which mammalian cells generate a truncated SV40 T-antigen.", NUCLEIC ACIDS RESEARCH, vol. 24, no. 9, 1996, pages 1653 - 1661, XP002251617, ISSN: 0305-1048
CONRAD R ET AL: "INSERTION OF PART OF AN INTRON INTO THE 5' UNTRANSLATED REGION OF A CAENORHABDITIS ELEGANS GENE CONVERTS ITS INTO A TRANS-SPLICED GENE", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 11, no. 4, April 1991 (1991-04-01), pages 1921 - 1926, XP001073410, ISSN: 0270-7306
EUL JOACHIM ET AL: "Experimental evidence for RNA trans-splicing in mammalian cells.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 14, no. 13, 1995, pages 3226 - 3235, XP001154331, ISSN: 0261-4189
EUL J ET AL: "Trans-splicing and alternative-tandem-cis-splicing: Two ways by which mammalian cells generate a truncated SV40 T-antigen.", NUCLEIC ACIDS RESEARCH, vol. 24, no. 9, 1996, pages 1653 - 1661, XP002251617, ISSN: 0305-1048
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