Title:
METHOD OF RESOLVING OPTICAL ISOMERS OF AMINO ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2002/036544
Kind Code:
A1
Abstract:
A method of resolving optical isomers which comprises mixing in an aqueous solution an amino acid derivative in the form of a mixture of D- and L-isomers (for example, N-(tert-butoxycarbonyl)-DL-alanine) with a hydrophilic compound isomers (for example, $g(b)-cyclodextrin), and then bringing the resultant aqueous solution or aqueous suspension into contact with a hydrophobic substance (for example, a solid having been subjected to a hydrophobic surface treatment) at pH 3.5 or lower or in the coexistence of an ion containing an atomic group capable of serving as a counter ion to the above-described amino acid derivative (for example, triethylammonium ion) to thereby resolve the D-amino acid derivative from the L-amino acid derivative which are contained in the aqueous solution or the aqueous suspension.
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Inventors:
WATANABE SHIN (JP)
KAWAHARA MIZUE (JP)
KAWAHARA MIZUE (JP)
Application Number:
PCT/JP2001/009384
Publication Date:
May 10, 2002
Filing Date:
October 25, 2001
Export Citation:
Assignee:
TOKUYAMA CORP (JP)
WATANABE SHIN (JP)
KAWAHARA MIZUE (JP)
WATANABE SHIN (JP)
KAWAHARA MIZUE (JP)
International Classes:
C07D207/16; C07B57/00; C07C231/20; C07C233/83; C07C269/08; C07C271/22; C07C319/28; C07C323/52; C07D209/20; C07C323/58; C07C323/59; (IPC1-7): C07C231/20; C07C233/83; C07C269/08; C07C271/22; C07C319/28; C07C323/58; C07D207/16; C07D209/20
Other References:
CHANG S.C. ET AL.: "Facile resolution of N-tert-butoxy-carbonyl amino acids: the importance of enantiomeric purity in peptide synthesis", JOURNAL OF LIQUID CHROMATOGRAPHY, vol. 15, no. 9, 1992, pages 1411 - 1429, XP002907641
Attorney, Agent or Firm:
Odajima, Heikichi (Akasaka 1-chome Minato-ku, Tokyo, JP)
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