Title:
METHOD FOR SCREENING ANTI-BREAST CANCER METASTASIS COMPOUND AND APPLICATION OF RELATED COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/049925
Kind Code:
A1
Abstract:
A method for screening an anti-breast cancer metastasis compound by using a tumor metastasis gene profile comprises randomly selecting at least one gene from the following 18 genes: MMP1, FSCN1, PTGS2, EREG, ANGPTL4, VCAM1, CXCR4, CXCL1, RARRES3, ID1, TNC, LY6E, LTBP1, C10orf116, KRTHB1, KYNU, MAN1A1, and NEDD9; and then designing a probe to select a compound that causes the expression levels of these metastasis genes in metastasized breast cancer cells to transition to those in cancer cells in situ or normal cells. Twenty compounds were selected using the method, and cytotoxicity and animal-level experiments demonstrated that these compounds or combinations thereof all exhibited activity against breast cancer metastasis at different degrees.
Inventors:
SHAO WEI (CN)
LI SHASHA (CN)
WANG DONG (CN)
LI SHASHA (CN)
WANG DONG (CN)
Application Number:
PCT/CN2017/094478
Publication Date:
March 22, 2018
Filing Date:
July 26, 2017
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
A61K31/12; C12Q1/68; A61K31/166; A61K31/192; A61K31/23; A61K31/353; A61K31/365; A61K31/437; A61K31/4409; A61K38/12; C12N15/11
Foreign References:
| US7829066B2 | 2010-11-09 | |||
| US20080213258A1 | 2008-09-04 | |||
| CN101171344A | 2008-04-30 |
Other References:
FANG, YAN: "Study on Breast Cancer Metastasis, Invasion Related Genes", CANCER RESEARCH AND CLINIC, vol. 16, no. 02, 30 April 2004 (2004-04-30), pages 138 - 140
ZHOU, HONGYING ET AL.: "Analysis of Differential Expression of Matrix Metalloproteinases in Breast Cancer Using Restriction Fragments Differential Display PCR", CHINESE JOURNAL OF ANATOMY, vol. 28, no. 03, 31 December 2005 (2005-12-31), pages 267 - 269
LAI, JINHUO ET AL.: "Expression and Clinical Significance of Idl in Breast Cancer: Analysis of 136 Cases", FUJIAN MEDICAL JOURNAL, vol. 30, no. 04, 31 August 2008 (2008-08-31), pages 94 - 96
ZHOU, HONGYING ET AL.: "Analysis of Differential Expression of Matrix Metalloproteinases in Breast Cancer Using Restriction Fragments Differential Display PCR", CHINESE JOURNAL OF ANATOMY, vol. 28, no. 03, 31 December 2005 (2005-12-31), pages 267 - 269
LAI, JINHUO ET AL.: "Expression and Clinical Significance of Idl in Breast Cancer: Analysis of 136 Cases", FUJIAN MEDICAL JOURNAL, vol. 30, no. 04, 31 August 2008 (2008-08-31), pages 94 - 96
Attorney, Agent or Firm:
LLR CHINA PATENT (CN)
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