Title:
METHOD OF SCREENING APOPTOSIS ACCELERATING COMPOUND OR ANTI-APOPTOTIC COMPOUND AND METHOD OF DETERMINING MALIGNANCY OF NEURODEGENERATIVE DISEASE
Document Type and Number:
WIPO Patent Application WO/2007/018238
Kind Code:
A1
Abstract:
A method of screening for determining whether to be an apoptosis accelerating compound or anti-apoptotic compound, comprising, under conditions of the presence and absence of a test compound, measuring the interaction between p53 and NEDL1 and comparing the intensities of interaction between p53 and NEDL1 measured in the presence and absence of the test compound.
Inventors:
NAKAGAWARA AKIRA (JP)
OZAKI TOSHINORI (JP)
OZAKI TOSHINORI (JP)
Application Number:
PCT/JP2006/315749
Publication Date:
February 15, 2007
Filing Date:
August 09, 2006
Export Citation:
Assignee:
HISAMITSU PHARMACEUTICAL CO (JP)
CHIBA PREFECTURE (JP)
NAKAGAWARA AKIRA (JP)
OZAKI TOSHINORI (JP)
CHIBA PREFECTURE (JP)
NAKAGAWARA AKIRA (JP)
OZAKI TOSHINORI (JP)
International Classes:
C12N15/09; C12Q1/02; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| WO2003018842A1 | 2003-03-06 | |||
| WO2003012102A2 | 2003-02-13 | |||
| WO2002090549A2 | 2002-11-14 |
Other References:
MIYAZAKI K. ET AL.: "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1", J. BIOL. CHEM., vol. 279, no. 12, 2004, pages 11327 - 11335, XP002295871
YANG Y. ET AL.: "Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells", CANCER CELL, vol. 7, June 2005 (2005-06-01), pages 547 - 559, XP003002753
MIYAZAKI K. ET AL.: "A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 308, no. 1, 2003, pages 106 - 113, XP004441426
YANG Y. ET AL.: "Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells", CANCER CELL, vol. 7, June 2005 (2005-06-01), pages 547 - 559, XP003002753
MIYAZAKI K. ET AL.: "A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 308, no. 1, 2003, pages 106 - 113, XP004441426
Attorney, Agent or Firm:
HASEGAWA, Yoshiki et al. (Ginza First Bldg. 10-6, Ginza 1-chom, Chuo-ku Tokyo, JP)
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