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Title:
METHOD FOR SCREENING FOR CANCER THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2016/159376
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for screening for a cancer therapeutic agent, which is a molecule targeting drug capable of targeting any one of great many target protein candidates, among from the target protein candidates without requiring the identification of a true target protein. The present invention can solve the above-mentioned problem by providing a method for screening for a cancer therapeutic agent, said method comprising the steps of: (i) allowing an exogenous cell regulation factor to be expressed in a cancer cell of interest while contacting or non-contacting the exogenous cell regulation factor with a test substance; (ii) confirming the change in the cancer cell; and (iii), when the change in the cancer cell under the contact with a test substance is increased compared with that under the non-contact with the test substance, selecting the test substance as a cancer therapeutic agent.

Inventors:
YAMADA YASUHIRO (JP)
SEMI KATSUNORI (JP)
WOLTJEN KNUT (JP)
MATSUDA YUTAKA (JP)
Application Number:
PCT/JP2016/060974
Publication Date:
October 06, 2016
Filing Date:
April 01, 2016
Export Citation:
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Assignee:
UNIV KYOTO (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12Q1/02; C12Q1/68; C12N15/09
Domestic Patent References:
WO2013126993A12013-09-06
Other References:
MATSUDA, Y. ET AL.: "Application of iPS cell technology to cancer epigenome study: Uncovering the mechanism of cell status conversion for drug resistance in tumor.", PATHOLOGY INTERNATIONAL, vol. 64, no. 7, July 2014 (2014-07-01), pages 299 - 308, XP055317309, ISSN: 1320-5463
KATSUNORI SEMI ET AL.: "Reprogramming Gijutsu o Mochiita Gan Epigenome Kenkyu", EXPERIMENTAL MEDICINE, vol. 32, no. 19, December 2014 (2014-12-01), pages 3061 - 3065, ISSN: 0288-5514
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
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