Title:
A METHOD FOR SCREENING CANCER
Document Type and Number:
WIPO Patent Application WO/2010/118559
Kind Code:
A1
Abstract:
A method for screening cancer comprises the following steps: (1) providing a test specimen; (2) detecting the methylation state of the CpG sequence in at least one target gene within the genomic DNA of the test specimen, wherein the target genes are consisted of PTPRR, ZNF582, PDE8B and DBC1; and (3) determining whether there is cancer or cancerous pathological change in the specimen based on the presence or absence of the methylation state in at least one target gene; wherein the method for detecting methylation state is methylation-specific PCR (MSP), quantitative methylation-specific PCR (QMSP), bisulfite sequencing (BS), microarrays, mass spectrometer, denaturing high-performance liquid chromatography (DHPLC) and the like.
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Inventors:
LAI HUNG-CHENG (CN)
Application Number:
PCT/CN2009/000411
Publication Date:
October 21, 2010
Filing Date:
April 17, 2009
Export Citation:
Assignee:
LAI HUNG-CHENG (CN)
International Classes:
C12Q1/68
Foreign References:
| CN101250588A | 2008-08-27 | |||
| TW200831900A | 2008-08-01 | |||
| CN200810094659A | 2008-04-29 | |||
| MYUI20085354A | 2008-12-30 | |||
| US20080311570A1 | 2008-12-18 |
Other References:
GRONBAEK K ET AL.: "Frequent hypermethylation of DBC1 in malignant lymphoproliferative neoplasms.", MOD PATHOL., vol. 21, no. 5, 2008, pages 632 - 638
LAI HC ET AL.: "Identification of novel DNA methylation markers in cervical cancer.", INT J CANCER., vol. 123, no. 1, 2008, pages 161 - 167, XP002543572, DOI: doi:10.1002/ijc.23519
SU HY ET AL.: "An epigenetic panel for screening and prognostic prediction of ovarian cancer.", INT J CANCER. JAN., vol. 124, no. 2, 2009, pages 387 - 393, XP055025294, DOI: doi:10.1002/ijc.23957
See also references of EP 2420578A4
LAI HC ET AL.: "Identification of novel DNA methylation markers in cervical cancer.", INT J CANCER., vol. 123, no. 1, 2008, pages 161 - 167, XP002543572, DOI: doi:10.1002/ijc.23519
SU HY ET AL.: "An epigenetic panel for screening and prognostic prediction of ovarian cancer.", INT J CANCER. JAN., vol. 124, no. 2, 2009, pages 387 - 393, XP055025294, DOI: doi:10.1002/ijc.23957
See also references of EP 2420578A4
Attorney, Agent or Firm:
KELONG INTERNATIONAL INTELLECTUAL PROPERTY AGENT LTD. (A-1303 Horizon International Tower,No. 6 Zhichun Roa, Haidian District Beijing 8, CN)
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