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Title:
METHOD OF SCREENING COMPOUND HAVING ANTIMICROBIAL ACTIVITY ON PATHOGENIC MICROORGANISM INFECTING ORGANISM HAVING ACQUIRED IMMUNE MECHANISM BY USING ORGANISM HAVING NATURAL IMMUNE MECHANISM ALONE, AND METHOD OF EVALUATING THE ANTIMICROBIAL ACTIVITY BY USING ORGANISM HAVING NATURAL IMMUNE MECHANISM ALONE
Document Type and Number:
WIPO Patent Application WO/2001/086287
Kind Code:
A1
Abstract:
It is examined whether or not silkworm larvae having a natural immune mechanism alone are useful as a system for evaluating an antimicrobial agent. It is found out that silkworm larvae die from infection by the injection of Micrococcus flavus or Pseudomonas aeruginosa. Effects of antimicrobial agents on silkworm larvae surprisingly agree with the clinical efficacies of these drugs on humans, i.e., an organism having an acquired immune mechanism.

Inventors:
Sekimizu, Kazuhisa (2-6-6, Minamisenzoku Ohta-ku, Tokyo, 145-0063, JP)
Application Number:
PCT/JP2001/003945
Publication Date:
November 15, 2001
Filing Date:
May 11, 2001
Export Citation:
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Assignee:
Sekimizu, Nobukazu (4-26-11, Nakaarai Tokorozawa-shi, Saitama, 359-0041, JP)
Sekimizu, Kazuhisa (2-6-6, Minamisenzoku Ohta-ku, Tokyo, 145-0063, JP)
International Classes:
G01N33/50; (IPC1-7): G01N33/15; A01K67/04; G01N33/50
Other References:
LEE A. BULLA JR. ET AL.: 'Bacteria as insect pathogens' ANNU. REV. MICROBIOL. vol. 29, 1975, pages 163 - 190, XP002944850
JULES A. HOFFMANN ET AL.: 'Phylogenetic perspectives in innate immunity' SCIENCE vol. 284, 1999, pages 1313 - 1318, XP002944847
GEORG JANDER ET AL.: 'Positive correlation between virulence of pseudomonas mutants in mice and insects' JOURNAL OF BACTERIOLOGY vol. 182, no. 13, 2000, pages 3843 - 3845, XP002944848
SHALINA MAHAJAN-MIKLOS: 'Elucidating the molecular mechnisms of bacterial virulence using non-mammalian hosts' MOLECULAR MICROBIOLOGY vol. 37, no. 5, 2000, pages 981 - 988, XP002944849
Attorney, Agent or Firm:
Shimizu, Hatsushi (Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki, 300-0847, JP)
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