Title:
METHOD FOR SCREENING COMPOUND FOR TREATING OR PREVENTING POLYQ-RELATED NEURODEGENERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO/2020/182143
Kind Code:
A1
Abstract:
The present invention relates to a method for screening or identifying a compound for treating or preventing polyQ-related neurodegenerative diseases, a compound obtained by the method and the use thereof.
Inventors:
LU BOXUN (CN)
FEI YIYAN (CN)
DING YU (CN)
DANG YONGJUN (CN)
FEI YIYAN (CN)
DING YU (CN)
DANG YONGJUN (CN)
Application Number:
PCT/CN2020/078775
Publication Date:
September 17, 2020
Filing Date:
March 11, 2020
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
G01N33/68; A61K31/352; A61K31/404; A61K31/517; A61P25/16; A61P25/28; G01N21/552; G01N21/64; G01N21/76; G01N25/48; G01N33/58
Domestic Patent References:
| WO2008021210A2 | 2008-02-21 | |||
| WO2004064733A2 | 2004-08-05 | |||
| WO2016114655A1 | 2016-07-21 | |||
| WO2010011964A2 | 2010-01-28 |
Foreign References:
| US20160296630A1 | 2016-10-13 |
Other References:
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NICOLE C MCKNIGHT, JEFFERIES HAROLD B J, ALEMU ENDALKACHEW A, SAUNDERS REBECCA E, HOWELL MICHAEL, JOHANSEN TERJE, TOOZE SHARON A: "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC", THE EMBO JOURNAL, vol. 31, no. 8, 21 February 2012 (2012-02-21), pages 1931 - 1946, XP055739920
LI ZHAOYANG; WANG CEN; WANG ZIYING; ZHU CHENGGANG; LI JIE; SHA TIAN; MA LIXIANG; GAO CHAO; YANG YI; SUN YIMIN; WANG JIAN; SUN XIAO: "Allele-selective lowering of mutant HTT protein by HTT-LC3 lin- ker compounds", NATURE, vol. 575, 30 October 2019 (2019-10-30), pages 203 - 209, XP036932218
LESLEY JONES ET AL.: "DNA repair in the trinucleotide repeat disorders", LANCET NEUROL., vol. 16, 2017, pages 88 - 96, XP029836611, DOI: 10.1016/S1474-4422(16)30350-7
"Uniprot", Database accession no. Q9GZQ8
CAS , no. 377090-84-1
WEISS ET AL., ANAL BIOCHEM, vol. 395, 2009, pages 8 - 15
SAPP ET AL., J BIOL CHEM, vol. 287, 2012, pages 13487 - 13499
KO ET AL., BRAIN RESEARCH BULLETIN, vol. 56, 2001, pages 319 - 329
MENALLED ET AL., J COMP NEUROL, vol. 465, 2003, pages 11 - 26
ZHU ET AL., SENSORS, vol. 16, no. 3, 2016, pages 378
FEI ET AL., J BIOMED OPT, vol. 15, no. 1, 2010, pages 016018
NICOLE C MCKNIGHT, JEFFERIES HAROLD B J, ALEMU ENDALKACHEW A, SAUNDERS REBECCA E, HOWELL MICHAEL, JOHANSEN TERJE, TOOZE SHARON A: "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC", THE EMBO JOURNAL, vol. 31, no. 8, 21 February 2012 (2012-02-21), pages 1931 - 1946, XP055739920
LI ZHAOYANG; WANG CEN; WANG ZIYING; ZHU CHENGGANG; LI JIE; SHA TIAN; MA LIXIANG; GAO CHAO; YANG YI; SUN YIMIN; WANG JIAN; SUN XIAO: "Allele-selective lowering of mutant HTT protein by HTT-LC3 lin- ker compounds", NATURE, vol. 575, 30 October 2019 (2019-10-30), pages 203 - 209, XP036932218
LESLEY JONES ET AL.: "DNA repair in the trinucleotide repeat disorders", LANCET NEUROL., vol. 16, 2017, pages 88 - 96, XP029836611, DOI: 10.1016/S1474-4422(16)30350-7
"Uniprot", Database accession no. Q9GZQ8
CAS , no. 377090-84-1
WEISS ET AL., ANAL BIOCHEM, vol. 395, 2009, pages 8 - 15
SAPP ET AL., J BIOL CHEM, vol. 287, 2012, pages 13487 - 13499
KO ET AL., BRAIN RESEARCH BULLETIN, vol. 56, 2001, pages 319 - 329
MENALLED ET AL., J COMP NEUROL, vol. 465, 2003, pages 11 - 26
ZHU ET AL., SENSORS, vol. 16, no. 3, 2016, pages 378
FEI ET AL., J BIOMED OPT, vol. 15, no. 1, 2010, pages 016018
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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