Title:
METHOD OF SCREENING FOR COMPOUNDS THAT ALTER SKIN AND/OR HAIR PIGMENTATION
Document Type and Number:
WIPO Patent Application WO2007138066
Kind Code:
A8
Abstract:
The invention provides a method of identifying compounds that either increase or decrease skin and/or hair pigmentation, the method comprising determining the ability of a test compound to modulate NCKX-mediated calcium ion movement across a membrane (e.g. NCKX5). The method may comprise the steps of exposing a membrane comprising a NCKX molecule or variant, fusion or derivative thereof to a test compound and measuring either directly or indirectly the calcium ion concentration on one or both sides of the membrane. The invention also relates to kits, nucleic acid molecules, polypeptides and cells useful in the method of the invention.
Inventors:
FILSELL WENDY (GB)
GINGER REBECCA SUSAN (GB)
GREEN MARTIN RICHARD (GB)
JARMAN CARL DUDLEY (GB)
OGBORNE RICHARD MARTIN (GB)
SCHNETKAMP PAUL P M (CA)
WILSON STEPHEN (GB)
GINGER REBECCA SUSAN (GB)
GREEN MARTIN RICHARD (GB)
JARMAN CARL DUDLEY (GB)
OGBORNE RICHARD MARTIN (GB)
SCHNETKAMP PAUL P M (CA)
WILSON STEPHEN (GB)
Application Number:
PCT/EP2007/055224
Publication Date:
June 26, 2008
Filing Date:
May 30, 2007
Export Citation:
Assignee:
UNILEVER NV (NL)
UNILEVER PLC (GB)
UNILEVER HINDUSTAN (IN)
FILSELL WENDY (GB)
GINGER REBECCA SUSAN (GB)
GREEN MARTIN RICHARD (GB)
JARMAN CARL DUDLEY (GB)
OGBORNE RICHARD MARTIN (GB)
SCHNETKAMP PAUL P M (CA)
WILSON STEPHEN (GB)
UNILEVER PLC (GB)
UNILEVER HINDUSTAN (IN)
FILSELL WENDY (GB)
GINGER REBECCA SUSAN (GB)
GREEN MARTIN RICHARD (GB)
JARMAN CARL DUDLEY (GB)
OGBORNE RICHARD MARTIN (GB)
SCHNETKAMP PAUL P M (CA)
WILSON STEPHEN (GB)
International Classes:
G01N33/50; G01N33/68
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