Title:
METHOD FOR SCREENING FOR FLAVOR MATERIAL HAVING MARINE NOTE
Document Type and Number:
WIPO Patent Application WO/2018/163800
Kind Code:
A1
Abstract:
The present invention provides a method for screening for a flavor material having a marine note. The screening method according to the present invention is a method for screening for a candidate compound having a marine note among from test compounds using an olfactory receptor having responsiveness to a flavor having a marine note, said method comprising the steps of: (i) bringing an olfactory receptor selected from the group consisting of OR10H5, OR10H4, OR10K1, OR2J2 and a protein that comprises an amino acid sequence having 80% or higher identity to an amino acid sequence represented by SEQ ID NO: 2, 4, 6 or 8 and has responsiveness to a flavor having a marine note into contact with a test compound and measuring the response of the olfactory receptor to the test compound; (ii) measuring the response of the olfactory receptor used in step (i) in the absence of the test compound; and (iii) comparing the measurement results obtained in step (i) with the measurement results obtained in step (ii) and selecting a test compound of which the response is changed as the candidate compound having a marine note.
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Inventors:
TERADA IKUO (JP)
OGATA MIHO (JP)
OGATA MIHO (JP)
Application Number:
PCT/JP2018/005930
Publication Date:
September 13, 2018
Filing Date:
February 20, 2018
Export Citation:
Assignee:
TAKASAGO PERFUMERY CO LTD (JP)
International Classes:
C12Q1/02; G01N33/497; G01N33/50; C07K14/705; C12N5/10; C12N15/12
Foreign References:
| US20150260707A1 | 2015-09-17 | |||
| JP2003284573A | 2003-10-07 |
Other References:
HUGEL H.M. ET AL.: "Marine fragrance chemistry", CHEM. BIODIVERS., vol. 5, no. 6, 2008, pages 1034 - 1044, XP055605210, DOI: 10.1002/cbdv.200890083
WILKIN F. ET AL.: "Deorphanization of human olfactory receptors", CHEM. SENSES, vol. 40, no. 3, 2015, pages 263
WILKIN F. ET AL.: "Deorphanization of human olfactory receptors", CHEM. SENSES, vol. 40, no. 3, 2015, pages 263
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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