Title:
METHOD OF SCREENING MATERIAL FOR IMPROVING DRY SKIN USING BLEOMYCIN HYDROLASE
Document Type and Number:
WIPO Patent Application WO/2012/074202
Kind Code:
A2
Abstract:
The present invention relates to a method of screening material for improving dry skin and provides a method of screening material for improving dry skin comprising screening on the basis of a change in gene expression of bleomycin hydrolase by a candidate material, and a material for improving dry skin found by screening. In addition, provided is a composition for a skin preparation for external use, containing a liver X receptor activator which increases the gene expression of bleomycin hydrolase as an active ingredient. The screening method of the present invention can find an effective material for improving dry skin, and the composition improves dry skin and prevents loss of skin moisture, thereby restoring the skin barrier of the stratum corneum.
Inventors:
SON EUI DONG (KR)
KIM YOON KYUNG (KR)
JOO KYUNG MI (KR)
KIM HYOUNG JUNE (KR)
LEE EUN KYUNG (KR)
NAM GAE WON (KR)
KIM JI HYUN (KR)
AHN SOO MI (KR)
KIM HAN KON (KR)
KIM YOON KYUNG (KR)
JOO KYUNG MI (KR)
KIM HYOUNG JUNE (KR)
LEE EUN KYUNG (KR)
NAM GAE WON (KR)
KIM JI HYUN (KR)
AHN SOO MI (KR)
KIM HAN KON (KR)
Application Number:
PCT/KR2011/007937
Publication Date:
June 07, 2012
Filing Date:
October 24, 2011
Export Citation:
Assignee:
AMOREPACIFIC CORP (KR)
SON EUI DONG (KR)
KIM YOON KYUNG (KR)
JOO KYUNG MI (KR)
KIM HYOUNG JUNE (KR)
LEE EUN KYUNG (KR)
NAM GAE WON (KR)
KIM JI HYUN (KR)
AHN SOO MI (KR)
KIM HAN KON (KR)
SON EUI DONG (KR)
KIM YOON KYUNG (KR)
JOO KYUNG MI (KR)
KIM HYOUNG JUNE (KR)
LEE EUN KYUNG (KR)
NAM GAE WON (KR)
KIM JI HYUN (KR)
AHN SOO MI (KR)
KIM HAN KON (KR)
International Classes:
C12Q1/34; A61K8/46; A61Q19/00; C12Q1/68
Domestic Patent References:
| WO2009142268A1 | 2009-11-26 |
Foreign References:
| US20080070883A1 | 2008-03-20 | |||
| US20020127223A1 | 2002-09-12 | |||
| US20020187157A1 | 2002-12-12 | |||
| US20030153541A1 | 2003-08-14 |
Other References:
HARINI SAMPATH, B.SC. ET AL.: 'Polyunsaturated Fatty Acid Regulation of Gene Expression.' NUTRITION REVIEWS. vol. 62, no. 9, 2004, pages 333 - 339
Attorney, Agent or Firm:
KIM, Sun-young (10th Floor 80-6,,Susong-Dong, Chongro-Ku, Seoul 110-727, KR)
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