Title:
METHOD FOR SCREENING TREATMENT TARGET FOR ACUTE RADIATION GASTROINTESTINAL SYNDROME, AND APPLICATION OF TIGAR TARGET IN PREPARATION OF DRUG FOR TREATING RADIATION GASTROINTESTINAL SYNDROME
Document Type and Number:
WIPO Patent Application WO/2021/212653
Kind Code:
A1
Abstract:
Provided is a method for screening a treatment target for an acute radiation gastrointestinal syndrome, specifically comprising: overexpressing a transgenic mice model using a CreERT-loxP condition, and after irradiating by a large dose of ionizing radiation, promoting the proliferation of stem cells in intestinal crypts at the resting stage so as to screen a treatment target for the radiation gastrointestinal syndrome which still has the treatment effect after irradiating for 18-24h. Also provided is an application of a TIGAR treatment target gene or protein in the preparation of a drug for treating a radiation gastrointestinal syndrome.
Inventors:
ZHANG HAOWEN (CN)
SHAO CHUNLIN (CN)
WANG ZHONGMIN (CN)
ZHANG YUSHUO (CN)
SHI XIAOLIN (CN)
WANG CHEN (CN)
WANG JINLU (CN)
DENG ZICHENG (CN)
LIN LONGXIN (CN)
CHEN FEI (CN)
REN HUANGGE (CN)
TANG QIMENG (CN)
DUAN HAOLIANG (CN)
FU BOWEN (CN)
LIU FENJU (CN)
SHAO CHUNLIN (CN)
WANG ZHONGMIN (CN)
ZHANG YUSHUO (CN)
SHI XIAOLIN (CN)
WANG CHEN (CN)
WANG JINLU (CN)
DENG ZICHENG (CN)
LIN LONGXIN (CN)
CHEN FEI (CN)
REN HUANGGE (CN)
TANG QIMENG (CN)
DUAN HAOLIANG (CN)
FU BOWEN (CN)
LIU FENJU (CN)
Application Number:
PCT/CN2020/098434
Publication Date:
October 28, 2021
Filing Date:
June 28, 2020
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C12N13/00; A01K67/027; A61K38/17; A61K48/00; A61P1/00; A61P39/06; C12N15/85
Domestic Patent References:
| WO2015016282A1 | 2015-02-05 |
Foreign References:
| CN110025398A | 2019-07-19 | |||
| CN101288602A | 2008-10-22 | |||
| CN104928254A | 2015-09-23 | |||
| CN103484540A | 2014-01-01 | |||
| CN106479983A | 2017-03-08 |
Other References:
P. LEE , AK HOCK , EC CHEUNG: "p53- and p73-independent Activation of TIGAR Expression in Vivo", CELL DEATH AND DISEASE, vol. 8, no. 6, 6 August 2015 (2015-08-06), pages 1 - 11, XP055860916, ISSN: 2041-4889, DOI: 10.1038/cddis.2015.205
LI XIAOQIN: "Establishment of A Model of Radiation-induced Intestinal Stem Cells Injury in Vitro and Screening the Target of Anti-radiation Drug", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 1 May 2018 (2018-05-01), pages 1 - 64, XP055860918, ISSN: 1674-0246
WILLIAMS JACQUELINE P., JACKSON ISABEL L., SHAH JUI R., CZARNIECKI CHRISTINE W., MAIDMENT BERT W., DICARLO ANDREA L.: "Animal Models and Medical Countermeasures Development for Radiation-Induced Lung Damage: Report from an NIAID Workshop", RADIATION RESEARCH, vol. 177, no. 5, 1 May 2012 (2012-05-01), US, pages 25 - 39, XP055860921, ISSN: 0033-7587, DOI: 10.1667/RROL04.1
LI XIAOQIN: "Establishment of A Model of Radiation-induced Intestinal Stem Cells Injury in Vitro and Screening the Target of Anti-radiation Drug", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 1 May 2018 (2018-05-01), pages 1 - 64, XP055860918, ISSN: 1674-0246
WILLIAMS JACQUELINE P., JACKSON ISABEL L., SHAH JUI R., CZARNIECKI CHRISTINE W., MAIDMENT BERT W., DICARLO ANDREA L.: "Animal Models and Medical Countermeasures Development for Radiation-Induced Lung Damage: Report from an NIAID Workshop", RADIATION RESEARCH, vol. 177, no. 5, 1 May 2012 (2012-05-01), US, pages 25 - 39, XP055860921, ISSN: 0033-7587, DOI: 10.1667/RROL04.1
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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